Media and Buffers in Dissolution Method Development Sink Conditions: Volume of medium should be at least 3 times that needed to form a saturated solution (USP definition) pH Range: Typical range is 1 1 to 6 8, but can be adjusted up to pH 8 0 for solubility
Overcoming sink limitations in dissolution testing: a review of . . . For realistic dissolution characterization, sink conditions, where saturation solubility of a drug in the dissolution medium is at least three times more than the drug concentration, are critical These conditions can be problematic to maintain with formulations containing poorly-soluble actives
What Is Sink Condition in Dissolution Testing? - Blog - Dissolution . . . Sink condition is the ability of the dissolution media to dissolve at least 3 times the amount of drug that is in your dosage form Having sink conditions helps your dissolution have more robustness as well as being more biologically relevant
Guide to Determine Sink Conditions in Dissolution Testing Understanding sink conditions is essential for accurate and reliable dissolution testing, which assesses the rate at which a drug substance dissolves in a dissolution medium