Conserved molecular players involved in human nose morphogenesis . . . Abstract Instances of repeated evolution of novel phenotypes can shed light on the conserved molecular mechanisms underlying morphological diversity A rare example of an exaggerated soft tissue phenotype is the formation of a snout flap in fishes
ACCEPTED MANUSCRIPT - ResearchGate onith et 18 exaggerated snout is a convergent phenotype that evolved independently in two cichlid lineages 19 that diverged > 9 MYA (Irisarri et al 2018; Conith et al 2019) 20
Investigating the case of human nose shape and climate . . . - PLOS Here, we investigate whether variation in the shape of the external nose across populations has been driven by regional differences in climate We find that variation in both nares width and alar base width appear to have experienced accelerated divergence across human populations
Conserved Molecular Players Involved in Human Nose Morphogenesis . . . p4 (tfap4), a transcription factor showing reduced expression in the flapped snout with an unknown role in craniofacial soft tissue development As genes involved in cichlid snout flap development are associated with human midline facial dysmorphologies, our findings hint at the conservation of genes invo
Conserved Molecular Players Involved in Human Nose Morphogenesis . . . We investigated the exaggerated snout in cichlid species from Lake Malawi and Lake Tanganyika and found that many genes involved in the development of the snout flap and are also associated with midline dysmorphologies in humans, implying a conservation across distant vertebrate lineages
RePub, Erasmus University Repository: Genomic evolution of . . . We determined the short (1 and 3 months) and mid-term (36 months) genomic evolution of S aureus in natural carriers and artificially colonized volunteers Eighty-five S aureus strains were collected from 6 natural carriers during 3 years and 6 artificially colonized volunteers during 1 month