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- Mitophagy - Wikipedia
Vacuoles containing mitochondria are marked with asterisks Mitophagy is the selective degradation of mitochondria by autophagy It often occurs to defective mitochondria following damage or stress The process of mitophagy was first described in 1915 by Margaret Reed Lewis and Warren Harmon Lewis [1]
- The mitophagy pathway and its implications in human diseases
Since the timely removal of abnormal mitochondria is essential for cell survival, cells have evolved a variety of mitophagy pathways to ensure that mitophagy can be activated in time under various environments
- Mitochondrial degradation: Mitophagy and beyond: Molecular Cell
Mitophagy is a selective form of macroautophagy (hereafter "autophagy") that cells use to degrade mitochondria During mitophagy, mitochondria are selectively sequestered within double-membrane vesicles called autophagosomes that deliver their mitochondrial cargo to lysosomes for degradation
- Molecular mechanisms and physiological functions of mitophagy
Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a fundamental mechanism conserved from yeast to humans that regulates mitochondrial quality and quantity control
- Mitophagy: An Emerging Role in Aging and Age-Associated Diseases
Here, we provide an update on mechanisms that control mitophagy, its role in aging and therapeutic interventions that harness mitophagy to treat age-related disorders
- The mitophagy pathway and its implications in human diseases
Here, we summarize the signaling pathways and mechanisms that regulate mitophagy Furthermore, we discuss how alterations in mitophagy affect mitochondrial homeostasis and disease development
- Mitophagy: An Emerging Role in Aging and Age-Associated Diseases
In this review, we summarize recent findings on mechanisms controlling mitophagy and its role in aging and the development of human pathologies Mitochondria are highly organized and dynamic organelles that undergo continuous fission and fusion (Chen and Chan, 2009; Pham et al , 2012)
- Mitophagy pathways in health and disease - PMC
Killackey et al review recent advances and major questions in the field of mitophagy, as well as implications for mitophagy in disease Mitophagy is an evolutionarily conserved process involving the autophagic targeting and clearance of mitochondria destined for removal
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