Anti-C1q in Systemic Lupus Erythematosus - PMC In SLE, anti-C1q are strongly associated with proliferative lupus nephritis, and their absence carries a negative predictive value for development of lupus nephritis of close to 100%
Anti-C1q antibodies: a biomarker for diagnosis and management of lupus . . . Some research suggests that the presence and changes in the titer of anti-C1qAb may be associated with the development of LN, as well as with LN activity and renal flares However, the exact role of anti-C1qAb in LN remains a subject of debate
Autoantibodies Illuminate Lupus Nephritis - The Rheumatologist Anti-C1q and antidouble- stranded DNA antibodies were independently associated with proliferative lupus nephritis In proliferative lupus nephritis, higher baseline anti-C1q antibody levels predicted complete response