Fluid shear stress regulates HepG2 cell migration though time-dependent . . . Our results showed that FSS endowed HepG2 cells with higher migration ability via reorganizing cellular F-actin and disrupting intercellular tight junctions We further demonstrated that FSS regulated the expression and translocation of Integrins and their downstream signaling cascade in time-dependent patterns
Fluid shear stress induces cell migration via RhoA-YAP1-autophagy . . . Our results indicate that LCSCs have stronger proliferation and cell spheroidization abilities FSS (1 dyn cm 2) upregulated the migration of LCSCs and autophagy protein markers, inducing LC3B aggregation and autophagosome formation in LCSCs
The detailed information of antibodies used in this study. The normal hepatic stellate cells LX2 were exposed to the medium or exosomes from the HepG2 cells with or without fluid shear stress subjection, and the CAFs activation markers were
Fluid shear stress induces cell migration and invasion via activating . . . The results showed that FSS induced autophagy in HepG2 cells through the integrin-cytoskeleton signaling pathway, and that inhibition of autophagy suppressed the migration and invasion of HCC cells, which might provide a novel treatment strategy for HCC
Fluid shear stress induces cell migration and invasion via activating . . . Fluid shear stress (FSS) regulates the metastasis of hepatocellular carcinoma (HCC) In the present study, we aimed to study the role of autophagy in HCC cells under FSS The results showed that FSS upregulated the protein markers of autophagy, induced LC3B aggregation and formation of autophagosome …