Tissue-Specific Gene Expression Changes are Associated with Aging in Mice We identified seven genes that were differentially expressed in all four tissues during aging, along with genes encoding various subunits of the mitochondrial electron transport chain (ETC) that were regulated in a similar fashion among the analyzed tissues
Aging signatures across diverse tissue cells in mice Using the TMS data, they identified aging-dependent genes in 76 cell types from 23 tissues They then characterised the aging behaviours of these genes that were both shared among all
Age-invariant genes: multi-tissue identification and characterization . . . However, no classical reference gene is appropriate across all aging tissues Instead, we provide novel tissue-specific and pan-tissue reference genes for assays utilizing gene normalization (RT-qPCR) that can be applied to mice across the lifespan
16183957443239 1. . 19 - eLife Abstract Aging is associated with complex molecular and cellular processes that are poorly understood Here we leveraged the Tabula Muris Senis single-cell RNA-seq data set to systematically characterize gene expression changes during aging across diverse cell types in the mouse