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- 3D‐Printed Biomimetic Vascular Scaffold Crosslinked with Heparan . . .
In this study, a biomimetic vascular scaffold crosslinked with heparan sulfate (HS) is developed to enable sustained delivery of the PDGFB-LG4 fusion protein, targeting the regeneration of critically sized bone defects
- PDGF BB and Its Role in Development and Disease
Stored in platelet α-granules, PDGF-BB is released upon platelet activation, playing a role in tissue remodeling However, other cells, including endothelial cells, fibroblasts, and tumor cells, also produce it
- Peripheral mural cell recruitment requires cell-autonomous heparan sulfate
N -sulfation of heparan sulfate (HS) is required for platelet-derived growth factor B (PDGF-B) retention and platelet-derived growth factor receptor-β (PDGFR-β) signaling during MC recruitment To analyze the specific role of MC-derived HS in this process, we inactivated HS synthesis in MCs
- Adult-induced genetic ablation distinguishes PDGFB roles in blood-brain . . .
Platelet-derived growth factor B (PDGFB) released from endothelial cells is indispensable for pericyte recruitment during angiogenesis in embryonic and postnatal organ growth
- Frontiers | Heparan Sulfate Biosynthesis and Sulfation Profiles as . . .
This review addresses the regulatory mechanisms underlying HS biosynthesis, with a particular focus on the catalytic activity of the enzymes responsible for HS glycan sequences and sulfation motifs, namely D-Glucuronyl C5-Epimerase, N- and O-Sulfotransferases
- CN107530371B - PDGF-B PDGF-BB binding variants of heparan sulfate . . .
The present invention relates to heparan sulphates that bind PDGF-B or PDGF-BB and to their use in wound healing, including skin repair and or regeneration
- Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and . . . - JCI
Overexpression of its ligand, PDGF-B, mediates the oncogenic influence of TGF-β in human GBM (12) and can drive tumorigenesis in murine models for glioma (13 – 15) Once released from the cell, growth factors can be sequestered by the extracellular microenvironment
- 3D-Printed Biomimetic Vascular Scaffold Crosslinked with Heparan . . .
In this study, a biomimetic vascular scaffold crosslinked with heparan sulfate (HS) is developed to enable sustained delivery of the PDGFB-LG4 fusion protein, targeting the regeneration of critically sized bone defects
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