- Tumour exosome integrins determine organotropic metastasis
Nature 2015 Nov 19;527 (7578):329-35 doi: 10 1038 nature15756 Epub 2015 Oct 28
- Tumour exosome integrins determine organotropic metastasis - Nature
Hoshino, A , Costa-Silva, B , Shen, TL et al Tumour exosome integrins determine organotropic metastasis Nature 527, 329–335 (2015) https: doi org 10 1038 nature15756
- Directional cell movement through tissues is controlled by . . . - Nature
Sung, B , Ketova, T , Hoshino, D et al Directional cell movement through tissues is controlled by exosome secretion Nat Commun 6, 7164 (2015) https: doi org 10 1038 ncomms8164
- Organ-seeking vesicles - Nature
Hoshino et al injected mice with exosomes followed by cancer cells from the same cell line, and demonstrated that the exosomes promoted organ-specific metastatic growth
- Directions to metastatic sites | Nature Reviews Cancer
Hoshino, Costa-Silva, Shen et al isolated and labelled exosomes from a series of cancer cell lines that metastasize to the lung (MDA-MB-231 cells) or liver (BxPC-3 and HPAF-II cells)
- Organotropic metastasis: role of tumor exosomes | Cell Research - Nature
A recent paper in Nature shows that tumor exosomes expressing unique integrins can determine organotropic metastasis by preparing pre-metastatic niche through their integrins-mediated fusion with
- Pancreatic cancer exosomes initiate pre-metastatic niche . . . - Nature
Melisi, D et al LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis
- Nature：外泌体整合素分子决定了肿瘤转移的器官倾向性
来自康奈尔大学的研究人员David Lyden等在Nature发表文章揭示了来自小鼠和人的肺、肝、脑等器官倾向性的肿瘤细胞外泌体倾向于与它们预计转移的目的器官的细胞（肺纤维细胞和上皮细胞、肝的kupffer细胞和脑的内皮细胞）相结合。
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