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- FABP4 attenuates PPARγ and adipogenesis and is inversely correlated . . .
Here we demonstrate that FABP4 triggers the ubiquitination and subsequent proteasomal degradation of peroxisome proliferator-activated receptor γ (PPARγ), a master regulator of adipogenesis and insulin responsiveness
- A FABP4-PPARγ signaling axis regulates human monocyte responses to . . .
PPARγ activation induces Fatty Acid Binding Protein 4 (FABP4) expression in human monocytes and macrophages FABP4 binds NO 2 -FA in vitro, suggesting its involvement in NO 2 -FA intracellular transport FABP4 participates in NO 2 -FAcell signaling actions in human monocytes
- Fatty acid-binding proteins: role in metabolic diseases and . . . - Nature
Adipocytes and macrophages jointly express two FABPs: A-FABP (also known as aP2 FABP4) and E-FABP (also known as mal1 FABP5), which are the best-studied FABPs They play a central role
- 白细胞介素 4 诱导的 FABP4 通过激活 PPAR γ 信号通路 . . .
The results show that fatty acid binding protein 4 (FABP4) participated in the peroxisome proliferator-activated receptor-γ (PPAR γ) signaling pathway as an up-regulated protein, which is related to lipogenesis in diverse cells
- PPAR的分子机制及其与疾病的关系 - 知乎
PPAR 在糖尿病和代谢综合征中具有重要作用。 PPAR-γ 通过改善胰岛素敏感性和调节脂肪代谢，帮助降低血糖；PPAR-α 促进脂肪酸氧化，降低甘油三酯水平；PPAR-δ 则影响能量代谢并改善胰岛素抵抗。 这些受体的激活有助于治疗糖尿病和减轻代谢综合征症状。
- FABP4 inhibition suppresses PPARγ activity and VLDL . . . - ScienceDirect
Macrophage lipid metabolism is transcriptionally regulated by peroxisome proliferator-activated receptor gamma (PPARγ), and its target gene fatty acid binding protein 4 (FABP4) accelerates the progression of atherosclerosis in mouse models
- 脂肪酸结合蛋白研究进展
PPAR与滋养层细胞的分化有关,它也调节FABPs在组织中的表达。 胎盘中FABPs的存在可能有助于脂肪酸等配体与PPAR结合,从而引起一些基因的表达。
- FABP4-PPARγ 信号轴调节人类单核细胞对亲电子脂肪酸 . . .
在此，我们探讨了单核细胞和巨噬细胞中 NO 2 -FA激活 PPARγ 相关的分子和细胞事件。 在单核细胞分化为巨噬细胞的早期阶段， NO 2 -FA 诱导两个 PPARγ 报告基因、脂肪酸结合蛋白 4 ( FABP4 ) 和清道夫受体 CD36 的表达。 这些反应被特定的 PPARγ 抑制剂 GW9662 抑制。 一旦细胞分化为巨噬细胞，就会观察到NO 2 -FA 对 PPARγ 信号传导的影响减弱， FABP4 上调显着但较低，且不诱导 CD36。 使用 体外 和 计算机 方法，我们证明了 NO 2 -FA 与 FABP4 结合。
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