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- ADAMTS13 - Wikipedia
ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13)—also known as von Willebrand factor-cleaving protease (VWFCP)—is a zinc -containing metalloprotease enzyme that cleaves von Willebrand factor (vWf), a large protein involved in blood clotting
- ADAMTS13 gene: MedlinePlus Genetics
The ADAMTS13 gene provides instructions for making an enzyme that is involved in regulating blood clotting After an injury, clots normally protect the body by sealing off damaged blood vessels and preventing further blood loss
- Recombinant ADAMTS13 in Congenital Thrombotic Thrombocytopenic Purpura
We are conducting a phase 3, multinational, prospective, open-label, randomized, controlled, two-period crossover trial to evaluate the efficacy and safety of recombinant ADAMTS13 and standard
- How do you differentiate and manage suspected ADAMTS13 (A Disintegrin . . .
In critically ill patients with thrombocytopenia and microangiopathic hemolytic anemia, immediately send ADAMTS13 activity testing while initiating empiric t
- ADAMTS13 Testing Overview - The Blood Project
ADAMTS13 (A Disintegrin And Metalloproteinase with Thrombospondin Motifs 13) is a protease that cleaves ultra-large von Willebrand factor (vWF) multimers An ADAMTS13 deficiency plays a key role in the pathogenesis of thrombotic thrombocytopenic purpura (TTP) 1
- ADAMTS13: origins, applications, and prospects - PubMed
Given ADAMTS13's key role in the cleavage of VWF and the prevention of PLT-rich thrombi within the microvasculature, future treatments may include anti-VWF therapeutics, recombinant ADAMTS13 infusions, and ADAMTS13 expression via gene therapy
- Gene test interpretation: ADAMTS13 (hereditary TTP gene) - UpToDate
This monograph discusses the implications of genetic test results for the ADAMTS13 gene, the gene that is abnormal in hereditary thrombotic thrombocytopenic purpura (hTTP, also called congenital TTP [cTTP])
- ADAMTS13 Activity Test: Key to Diagnosing Blood Clotting Disorders
The ADAMTS13 activity test is a vital diagnostic tool for identifying blood clotting disorders, including thrombotic thrombocytopenic purpura (TTP) By measuring the activity of the ADAMTS13 enzyme, this test provides critical insights into conditions such as ADAMTS13 deficiency
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