- Does Estrogen Put the Brakes on Aging in ApoE4-Positive Cells?
White blood cells age quickly in post-menopausal women who carry the ApoE4 gene, but estrogen slows that decline, scientists report February 13 in PLoS ONE Natalie Rasgon at Stanford University School of Medicine, California, and colleagues found that telomeres, the protective chromosome ends that
- ALZ-801 | ALZFORUM
It enrolled 325 ApoE4 homozygotes with clinically diagnosed early to mild AD Participants received 265 mg of ALZ-801 or placebo twice daily for 18 months The primary efficacy endpoint is change in ADAS-COG13; secondary endpoints include disability assessment for dementia (DAD), CDR-SB, and the Amsterdam-iADL
- APOE | ALZFORUM
APOE encodes a secreted apolipoprotein involved in lipid metabolism It is best known for its three major alleles—APOE2, APOE3, and APOE4 —with APOE4 increasing the risk for Alzheimer’s disease and APOE2 reducing it Every person has an APOE genotype determined by pairs of these alleles: APOE3 E3 (the most common), APOE3 E4, APOE3 E2, APOE2 E4, APOE4 E4, or APOE2 E2 Other variants
- ApoE4 Makes All Things Tau Worse, From Beginning to End
Deleting ApoE from FTD tau mice protects them against neurodegeneration ApoE, especially E4, increases tau accumulation, redistribution to neuronal cell bodies, neuroinflammation, and brain atrophy In human non-Aβ tauopathies, ApoE4 carriers have worse neurodegeneration; in AD, ApoE4 carriers progress faster
- CS6253 - ALZFORUM
The company is developing CS6253 for ApoE4-driven Alzheimer’s disease Designed to mimic sequences at the carboxy terminus of ApoE, CS96253 was shown to enhance ABCA1-mediated lipid efflux from cells and formation of HDL particles in vitro (Hafiane et al , 2015; Hafiane et al , 2019)
- APOE | ALZFORUM
ApoE has three isoforms— ApoE2, E3, and E4 —with unique cysteine arginine combinations at positions 130 and 176 Every person has an APOE genotype determined by homozygous or heterozygous pairs of the alleles encoding these isoforms—for example, APOE3 E3 or APOE3 E4 The APOE4 allele is thought to be the ancestral form of the APOE gene which gave rise to APOE2 and APOE3
- Leqembi in the Clinic: So Far, ARIA Echoes Trials | ALZFORUM
The scientists reported that so far, adverse events in clinical practice resemble those in the trials In some settings, rates of ARIA-E are lower than expected, perhaps because many medical centers exclude APOE4 homozygotes In support of withholding lecanemab from this group of patients, Stefan Teipel at the German Center of Neurodegenerative Diseases, Rostock, presented a Bayesian
- Amelioration of Tau and ApoE4-linked glial lipid . . . - ALZFORUM
Here, Alexandra Litvinchuk from David Holtzman’s laboratory investigated the effect of the LXR agonist GW3965 as well as overexpression of ABCA1 on tau and apoE4-linked glial lipid accumulation and neurodegeneration
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