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- Apamin - Wikipedia
Apamin is the only neurotoxin acting purely on the central nervous system The symptoms of apamin toxicity are not well known, because people are not easily exposed to the toxin alone
- Apamin structure and pharmacology revisited - PMC
Apamin is often cited as one of the few substances selectively acting on small-conductance Ca 2+ -activated potassium channels (K Ca 2) However, published pharmacological and structural data remain controversial
- What Is Apamin and What Does This Compound Do?
Apamin is a small but potent neurotoxin, a substance that affects the nervous system Derived from bee venom, its unique properties allow it to interact with the body in specific ways, leading to various physiological effects
- Mechanism of SK2 channel gating and its modulation by the bee toxin . . .
Cryo-EM and electrophysiology reveal the mechanism of SK2 channel modulation by the bee toxin apamin and small molecules, providing insights that enable the rational design of targeted SK2 channel therapeutics
- Apamin - an overview | ScienceDirect Topics
Apamin is defined as an 18 amino-acid peptide neurotoxin found in bee venom that selectively blocks small conductance SK channels, which are a class of Ca-dependent K+ channels It has been shown to reduce all stages of sleep and decrease the propensity to enter REM sleep in animal studies
- Apamin (Apamine) | Potassium Channel Inhibitor | MedChemExpress
Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity
- Apamin | Calcium-Activated Potassium (KCa) Channels | Tocris Bioscience
Apamin is a potent and highly selective inhibitor of small-conductance Ca 2+ -activated K + -channels (K Ca 2, SK) (IC 50 values are 87 7 pM, 2 3 nM and 4 1 nM for K Ca 2 2, K Ca 2 3 and K Ca 2 1 channels, respectively) Reduces release and mRNA expression of inflammatory cytokines TNFα and IL-6
- Apamin structure and pharmacology revisited - Frontiers
Apamin is often cited as one of the few substances selectively acting on small-conductance Ca 2+ -activated potassium channels (K Ca 2) However, published pharmacological and structural data remain controversial
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