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- BRCA Gene Changes: Cancer Risk and Genetic Testing
The prevalence of harmful BRCA gene changes in the general population is about 0 2%–0 3% (or about 1 in 400) However, in certain populations that are geographically or culturally distinct, the prevalence of specific BRCA mutations—called founder mutations—is higher
- BRCA1 and BRCA2 (PDQ®) - NCI - National Cancer Institute
Key points: BRCA1 2 -associated ovarian cancers are more likely to have high-grade serous adenocarcinoma histologies Occult lesions found in the fallopian tubes of BRCA carriers suggest that many BRCA -associated ovarian cancers may originate in the fallopian tubes
- Hoja informativa sobre los cambios en el gen BRCA y las pruebas genéticas
Los cambios dañinos en BRCA que se detectan en el tumor pueden ser hereditarios o haber surgido en otro momento de la vida de la persona Por este motivo, si se identifica un cambio en el tumor, es importante hacerse una prueba para averiguar si es hereditario
- Discovery – BRCA Connection to Breast and Ovarian Cancer
As a result of NCI's investment, people with a family history of breast and ovarian cancer can use their BRCA test results to help make informed decisions about screening and potential risk-reducing treatment
- MRI, Surgery Reduce Cancer Deaths in Women with BRCA Changes
For women with inherited harmful changes in BRCA genes, MRI surveillance and salpingo-oophorectomy can modestly reduce their risk of dying from breast and ovarian cancer, results from two studies show
- Researchers categorize thousands of BRCA2 mutations as cancerous or . . .
A team of researchers led by Shyam K Sharan, Ph D , Senior Investigator in the Mouse Cancer Genetics Program, has categorized over 6,500 possible single nucleotide variants (SNVs) in the BRCA2 protein as either benign or potentially cancerous The study was published in Nature on February 13, 2025 BRCA2 is a protein that is involved in repairing DNA and maintaining the integrity of the
- Cancer Risk for Women Carrying BRCA Mutations - NCI
An international team of researchers has published results from the first large prospective study of breast and ovarian cancer risk in women who carry inherited BRCA mutations The BRCA1 and BRCA2 genes code for proteins that are critical for cells to repair damaged DNA
- Causes and Risk Factors | Breast Cancer - NCI
BRCA1 and BRCA2 (learn more at BRCA Gene Changes: Cancer Risk and Genetic Testing) PALB2 CHEK2 TP53 (Li-Fraumeni syndrome) CDH1 PTEN (Cowden syndrome and PTEN hamartoma tumor syndrome) STK11 (Peutz-Jeghers syndrome) ATM having a family history of breast cancer
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