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- Immunophenotypic and Cytogenetic Analysis of Molt-3 and Molt-4: Human T . . .
Molt-3 and Molt-4 had immunophenotypic characteristics of thymocytes with expression of CD1 and CD5 Both cell lines had a hypertetraploid karyotype with two rearranged no 7 chromosomes: 2der (7)t (7;7) (p15;q11) The presence of a break in chromosome band 7p15 suggested the involvement of T gamma
- Immunophenotypic and cytogenetic analysis of Molt-3 and Molt-4 . . . - PubMed
Molt-3 and Molt-4 had immunophenotypic characteristics of thymocytes with expression of CD1 and CD5 Both cell lines had a hypertetraploid karyotype with two rearranged no 7 chromosomes: 2der (7)t (7;7) (p15;q11) The presence of a break in chromosome band 7p15 suggested the involvement of T gamma
- Chimeric antigen receptor T-cell therapy for T-ALL and AML
The optimal antigen response of chimeric antigen receptors harboring the Cd3zeta transmembrane domain is dependent upon incorporation of the receptor into the endogenous Tcr Cd3 complex J Immunol (2010) 184(12):6938–49 doi: 10 4049 jimmunol 0901766 [ DOI ] [ PubMed ] [ Google Scholar ]
- TCR β chain–directed bispecific antibodies for the . . . - Science
Usually, one scFv is directed against a cancer tissue–specific antigen and the other scFv targets the T cell–activating molecule CD3 The dual binding of cancer cell and T cell results in T cell–mediated cancer cell death
- Abstract - American Society of Hematology
Molt-3 and Molt-4 had immunophenotypic characteristics of thymocytes with expression of CD1 and CD5 Both cell lines had a hypertetraploid karyotype with two rearranged no 7 chromosomes: 2der (7)t (7;7) (p15;q11) The presence of a break in chromosome band 7p15 suggested the involvement of T gamma
- MOLT-3 - CRL-1552 - ATCC
MOLT-3 is a T lymphoblast cell line that was isolated from the peripheral blood of a 19-year-old, male patient with acute lymphoblastic leukemia This cell line was deposited by J Minowada It can be used in immune system disorders, immunology, and immuno-oncology research You were successfully signed up for notification
- Synergistic Effects of Interleukin-7 and Pre-T Cell Receptor Signaling . . .
IL-7 promoted pre-TCR activation in IL-7Rα hi Molt3 as illustrated by CD25 up-regulation after anti-CD3 stimulation Anti-CD3 treatment activated Akt and Erk1 2 signaling pathways as proven using specific inhibitors, and IL-7 further enhanced both signaling pathways
- FIGURE 2. Analysis of IL-7 and anti-CD3 signaling in lentiviral. . .
To study this, we engineered Molt3, a T cell progenitor T-acute lymphoblastic leukemia cell line, using lentiviral IL-7 receptor α (IL-7Rα) to serve as a model system IL-7 promoted pre-TCR
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