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- Claudin - Wikipedia
Claudin Claudins are a family of proteins which, along with occludin, are the most important components of the tight junctions (zonulae occludentes) [1][2] Tight junctions establish the paracellular barrier that controls the flow of molecules in the intercellular space between the cells of an epithelium [1][3][4] They have four transmembrane
- Claudins靶点梳理 - 知乎
Claudin-1是一种新型靶点，具有独特的作用机制，在肝纤维化和纤维化驱动型肝胆癌的病理中发挥关键作用。 Claudin1靶向药物目前有ALE-F02处于1期临床研究、ALE-C04处于临床前研究。
- 什么是Claudin家族？ - 知乎
文献表明，Claudin-1是表皮紧密连接结构和功能完整性的关键蛋白。它直接参与形成细胞间的密封屏障，是防止水溶性物质和离子通过细胞旁路径流失或入侵的主要物理屏障；一旦它缺失，后果就会很严重！实验证明，无论是基因敲除小鼠还是人类遗传疾病（如
- 病理科普 | 一文带你了解Claudin18. 2蛋白表达检测-MedSci. cn
Claudin（CLDN）蛋白家族是构成紧密性连接复合体（Tight junctions，TJs）的重要组成及功能结构，包含至少 27 个家族成员，是定位于细胞膜表面的跨膜蛋白。
- Claudins: Control of Barrier Function and Regulation in Response to . . .
Claudins are a family of nearly two dozen transmembrane proteins that are a key part of the tight junction barrier that regulates solute movement across polarized epithelia Claudin family members interact with each other, as well as with other
- Structure and Function of the Claudin Family - BPS Bioscience
Discover BPS Bioscience’s resources on the claudin family of proteins Explore our tools and research solutions for studying claudins’ roles in tight junctions, cell adhesion, and disease
- CLDN3：极为关键的紧密连接蛋白，Claudins家族再添药物靶点！ 研究热点|生物学前沿技术|行业研究 -武汉华美生物
Claudin主要作用是维持细胞间的物理屏障功能及细胞极性。 肿瘤的发生、发展及转移是一个多因素造成的分阶段过程，但是目前普遍认为细胞间的黏附力丧失可导致细胞紧密连接破坏，与肿瘤细胞的浸润和转移相关，这使得Claudin家族成为备受关注的治疗靶点 [2]。
- Structure and function of claudins - ScienceDirect
Phosphorylation can be catalyzed by mitogen-activated protein kinase (Thr203, rat) [32] and protein kinase C [33] in claudin-1, or by protein kinase A in claudin-3 (Thr192, human) [34] and claudin-5 (Thr207, rat) [35]
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