- ERK MAPK signalling pathway and tumorigenesis - PMC
Extracellular signal-regulated kinase 1 2 (ERK) belongs to the mitogen-activated protein kinase (MAPK) family, which plays a role in signalling cascades and transmits extracellular signals to intracellular targets
- ERK signalling: a master regulator of cell behaviour, life and fate
By phosphorylating widely diverse substrates, ERK proteins govern a variety of evolutionarily conserved cellular processes in metazoans, the dysregulation of which contributes to the cause of
- Erk Signaling | Cell Signaling Technology
The MAPK Erk signaling cascade is activated by a wide variety of receptors involved in growth and differentiation including receptor tyrosine kinases (RTKs), integrins, and ion channels
- Extracellular Signal-Regulated Kinases: One Pathway, Multiple Fates - MDPI
The ERK pathway is a key cell signaling system activated by physiological factors or oncogenic mutations, influencing different cell outcomes The protein kinases ERK1 and ERK2 (ERK) acting at the end of the pathway control whether cells grow, differentiate, age, or die
- MAPK ERK pathway - Wikipedia
The ERK pathway plays an important role of integrating external signals from the presence of mitogens such as epidermal growth factor (EGF) into signaling events promoting cell growth and proliferation in many mammalian cell types
- Extracellular Signal-Regulated Kinase: A Regulator of Cell Growth . . .
Extracellular signal-regulated kinase (ERK) is a member of the mitogen-activated protein kinase family of signaling molecules ERK is predominantly found in two forms, ERK1 (p44) and ERK2 (p42), respectively There are also several atypical forms of ERK, including ERK3, ERK4, ERK5 and ERK7
- From Surface to Nucleus: Understanding the ERK MAPK Signaling . . . - Qiagen
ERK: The final kinase in the cascade, which, once activated, travels to the nucleus to regulate gene expression This cascade amplifies the signal and ultimately leads to changes in gene expression in the nucleus, affecting the cell's behavior
- MAPK1 - Wikipedia
MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development
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