- 16. 3: Regulation of the Citric Acid Cycle - Biology LibreTexts
This chapter explores the complex regulation of energy extraction via the citric acid cycle (CAC) and the pyruvate dehydrogenase complex (PDC), emphasizing how these pathways are finely tuned to meet cellular and systemic energy demands
- Citric acid cycle - Wikipedia
Through catabolism of sugars, fats, and proteins, the two-carbon organic product acetyl-CoA is produced which enters the citric acid cycle
- Regulation of TCA Cycle - Creative Proteomics
The tricarboxylic acid cycle (TCA cycle, or citric acid cycle) is governed not only by enzymatic activity but also by transcriptional regulation, enabling long-term adaptation to cellular energy states, oxygen availability, and environmental cues
- Regulation of the Citric Acid Cycle: Key Enzymes and Pathways
Following the production of citrate, the cycle goes through several oxidative decarboxylation and hydration steps The enzyme isocitrate dehydrogenase, which changes isocitrate to alpha-ketoglutarate, is essential for cycle regulation This enzyme is effectively regulated by ATP and ADP
- Tricarboxylic Acid Cycle - Springer
In 1937, Hans Krebs postulated the citric acid cycle based on previous findings by Szent-Gyorgyi and his own findings that citrate catalytically stimulates respiration and is converted to α-ketoglutarate and then to succinate
- Krebs Cycle: A Comprehensive Guide - Nurseslab. in
The Krebs cycle, or citric acid cycle, occurs in mitochondria and oxidizes acetyl-CoA to generate ATP, NADH, and FADH₂ This process supports energy production, metabolism, and cellular respiration—essential in physiology, nursing, and medical education
- The Tricarboxylic Acid Cycle Background (why are eight enzymes necessary?)
Production of TCA cycle intermediates can increase the capacity to perform the TCA cycle, or can act as a mechanism for converting one TCA cycle intermediate to another to allow interchange of biosynthetic intermediates from one pathway to another
- Tricarboxylic Acid (TCA) Cycle – biochemistry
We will discuss the importance of the pyruvate dehydrogenase reaction as a first step for acetyl-CoA entry into the TCA cycle We will describe the cycle itself, its regulation, and the shuttling of electrons through the electron transport chain (ETC) to generate ATP SLO1: 1
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