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- Clinical effectiveness of fresh frozen plasma compared with fibrinogen . . .
Introduction Haemostatic therapy in surgical and or massive trauma patients typically involves transfusion of fresh frozen plasma (FFP) Purified human fibrinogen concentrate may offer an alternative to FFP in some instances In this systematic review, we investigated the current evidence for the use of FFP and fibrinogen concentrate in the perioperative or massive trauma setting Methods
- A national study of plasma use in critical care: clinical indications . . .
Introduction Fresh frozen plasma (FFP) is widely used, but few studies have described patterns of plasma use in critical care We carried out a multicentre study of coagulopathy in intensive care units (ICUs) and here describe overall FFP utilisation in adult critical care, the indications for transfusions, factors indicating the doses used and the effects of FFP use on coagulation Methods We
- Balanced massive transfusion ratios in multiple injury patients with . . .
Introduction Retrospective studies have demonstrated a potential survival benefit from transfusion strategies using an early and more balanced ratio between fresh frozen plasma (FFP) concentration and packed red blood cell (pRBC) transfusions in patients with acute traumatic coagulopathy requiring massive transfusions These results have mostly been derived from non-head-injured patients The
- Clinical review: Prothrombin complex concentrates - evaluation of . . .
The aims of the present review are to provide a systematic overview of thrombotic complications reported with PCCs, to examine the possible pathogenesis of thrombotic events, and to discuss safety precautions and means to reduce thrombotic complications Furthermore, the review performs a critical comparison of PCC with FFP
- Transfusion in trauma: thromboelastometry-guided coagulation factor . . .
Introduction Thromboelastometry (TEM)-guided haemostatic therapy with fibrinogen concentrate and prothrombin complex concentrate (PCC) in trauma patients may reduce the need for transfusion of red blood cells (RBC) or platelet concentrate, compared with fresh frozen plasma (FFP)-based haemostatic therapy Methods This retrospective analysis compared patients from the Salzburg Trauma Centre
- Effect of transfusion of fresh frozen plasma on parameters of . . .
Introduction Much controversy exists on the effect of a fresh frozen plasma (FFP) transfusion on systemic inflammation and endothelial damage Adverse effects of FFP have been well described, including acute lung injury However, it is also suggested that a higher amount of FFP decreases mortality in trauma patients requiring a massive transfusion Furthermore, FFP has an endothelial
- Prothrombin complex concentrate versus fresh frozen plasma in patients . . .
To reverse oral anticoagulant (OAC) therapy, a number of treatment modalities is available Fresh frozen plasma (FFP) is effective and is currently used for coagulation factor replacement, carrying a risk of volume overload, transmission of infective agents and being time consuming Variable and frequently low potency of clotting factors results in minor haemostatic effects compared with
- Pre-hospital plasma transfusion: a valuable coagulation support or an . . .
Moreover, the INR of FFP is 1 3 [6] Any beneficial effect of plasma to correct slightly elevated INR is futile and plasma has primarily an effect on coagulation parameters with extended volumes and performs best in patients bleeding and coagulopathic
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