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- Long-read sequencing unveils high-resolution HPV integration . . . - Nature
Integration of human papillomavirus (HPV) DNA into the human genome is considered as a key event in cervical carcinogenesis
- Precise identification of viral–host integration events in HPV-positive . . .
Human papillomaviral (HPV) integrations into host human genome, a frequently observed event in HPV associated cervical cancer, are currently mapped through expensive Whole Genome sequencing (WGS) or RNA sequencing (RNA-seq) methodologies
- HPV integration and cervical cancer: a failed evolutionary viral trait
HPV causing cervical cancer can therefore be perceived as a failed evolutionary viral trait Here we outline the occurrence and mechanisms of HPV integration and how this process results in oncogenic transformation
- HPV Integration: Moving From Carcinogenesis Mechanisms to Clinical . . .
Here, we summarize current insights into the mechanisms of HPV integration, highlight their clinical implications for the diagnosis, prevention, and treatment of HPV-related cancers, and discuss emerging molecular therapeutic strategies with the potential to advance precision oncology in this field
- HPV integration generates a cellular super-enhancer which . . . - PubMed
Human papillomavirus (HPV) integration is a critical step in cervical cancer development; however, the oncogenic mechanism at the genome-wide transcriptional level is still poorly understood
- 马丁院士团队：全面揭示两种HPV整合状态宫颈癌的分子特征_澎湃号·湃客_澎湃新闻-The Paper
该研究全面揭示了两种HPV整合状态宫颈癌的分子特征，并证明了转录型HPV整合与肿瘤侵袭、免疫逃逸和进展相关，为了解HPV整合驱动的宫颈癌发生、进展提供了全新的理论依据，为宫颈癌的早期筛查和分流提供了重要的手段和工具。
- Frontiers | Multiple HPV integration mode in the cell lines based on . . .
Our study not only clarified the feasibility of high-throughput long-read sequencing in the study of HPV integration, but also explored a variety of HPV integration models, and confirmed that viral integration is an important form of HPV in cell lines
- Human papillomavirus integration transforms chromatin to drive . . .
Abstract Background Human papillomavirus (HPV) drives almost all cervical cancers and up to 70% of head and neck cancers Frequent integration into the host genome occurs predominantly in tumorigenic types of HPV
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