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- Galectin - Wikipedia
Galectins are a class of proteins that bind specifically to β-galactoside sugars, such as N -acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation They are also termed S-type lectins due to their dependency on disulphide bonds for stability and carbohydrate binding
- Galectin Therapeutics
Galectin Therapeutics develops novel therapies to improve the lives of patients with chronic liver disease and cancer Galectin’s lead drug, belapectin (GR‑MD‑02), is a carbohydrate-based drug that inhibits the galectin‑3 protein, involved in many inflammatory, fibrotic, and malignant diseases
- The role of galectins in immunity and infection - Nature
The galectin family consists of carbohydrate (glycan) binding proteins that are expressed by a wide variety of cells and bind to galactose-containing glycans Galectins can be located in the
- Galectin-3 as a novel biomarker for disease diagnosis and a target for . . .
Galectin-3 is a member of the galectin family, which are β-galactoside-binding lectins with ≥1 evolutionary conserved carbohydrate-recognition domain It binds proteins in a carbohydrate-dependent and -independent manner
- Galectins: Current Biology - Cell Press
Galectins are β-galactoside-binding animal lectins that contain one or two conserved carbohydrate recognition domains (CRDs) consisting of approximately 130 amino acids
- Galectin-3 - Wikipedia
Overexpression and changes in the localization of galectin-3 molecules affects the prognosis of the patient and targeting the actions of galectin-3 poses a promising therapeutic strategy for the development of effective therapeutic agents for cancer treatment
- Galectins - Essentials of Glycobiology - NCBI Bookshelf
Galectins are among the most widely expressed class of lectins in all organisms They typically bind β-galactose-containing glycoconjugates and share primary structural homology in their carbohydrate-recognition domains (CRDs)
- Targeting galectin-3 in inflammatory and fibrotic diseases
Galectin (Gal)-3 is a β-galactoside-binding lectin emerging as a key player in cardiac, hepatic, renal, and pulmonary fibrosis and inflammation, respiratory infections caused by COVID-19, and neuroinflammatory disorders
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