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- Gliomas - Symptoms, diagnosis and treatment | BMJ Best Practice
Gliomas are primary tumours of the brain arising from glial progenitor cells Normal glia (astrocytes and oligodendrocytes) provide structural and metabolic support to the brain and neurons, regulate ion concentrations in the extracellular space, modulate synaptic transmissions, and take up and release neurotransmitters Gliomas may be circumscribed or diffuse
- Gliomas - Sintomas, diagnóstico e tratamento | BMJ Best Practice
Gliomas com mutações em H3 (tais como glioma de linha média difuso, com alterações em H3 K27M; e glioma hemisférico difuso, com mutações em H3 G34) são tumores cerebrais agressivos (grau 4) que ocorrem em crianças, adolescentes e adultos jovens
- Long QT syndrome - BMJ Best Practice
Long QT syndrome (LQTS) is a congenital or acquired condition that is characterised by a prolonged QT interval on the surface ECG and is associated with a high risk of sudden cardiac death due to ventricular tachyarrhythmias In congenital LQTS, mutations within 17 identified genes result in a variety of channelopathies affecting myocardial repolarisation, thus prolonging the QT interval
- Tumour lysis syndrome - BMJ Best Practice
Tumour lysis syndrome (TLS) is an oncological emergency caused by rapid breakdown of cancer cells and subsequent release of large amounts of intracellular content into the bloodstream The pathophysiological manifestations of TLS can lead to acute kidney injury, cardiac arrhythmias, seizures, and
- Sintomas, diagnóstico e tratamento - BMJ Best Practice
O meningioma é um tumor das meninges predominantemente não maligno que ocorre nas regiões craniana e espinhal Pode ser assintomático ou causar sintomas decorrentes do efeito de massa local por compressão de estruturas neurais O diagnóstico é confirmado pela aparência característica à ressonânci
- Neurofibromatose do tipo 1 - BMJ Best Practice
A neurofibromatose do tipo 1 (NF1) é um distúrbio genético autossômico dominante definida pelas características de manchas café-com-leite, múltiplos neurofibromas e nódulos de Lisch na íris O diagnóstico é feito clinicamente; são recomendados testes moleculares baseados em RNA da mutação de NF1
- Symptoms, diagnosis and treatment - BMJ Best Practice
Soft-tissue sarcoma (STS) is a group of rare solid tumours of connective tissue More than 50 different histological subtypes are known Most commonly, it presents as a soft-tissue swelling, which may or may not be painful Differential diagnoses that should be considered are lymphoma, metastatic
- Symptoms, diagnosis and treatment - BMJ Best Practice
Medulloblastoma is a malignant, invasive brain tumour arising from the cerebellum It is the most common malignant brain tumour of childhood Symptoms, due to a mass effect from the tumour or to obstructive hydrocephalus, include morning headaches, nausea, vomiting, diplopia (manifestation of six
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