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- Insights on the functional dualism of nitric oxide in the hallmarks of . . .
Nitric oxide's effects on cancer have been extensively studied, however the dichotomous roles that NO plays in tumour and tumour-associated cells exacerbate the already dysregulated metabolic pathways of cancer
- The Role of Nitric Oxide in Cancer Treatment: Ally or Foe?
In many tumors with TP53 gene mutations, increased iNOS expression is observed, leading to elevated nitric oxide (NO) levels, which is associated with a more aggressive tumor phenotype—increased cell proliferation, migration, and invasiveness
- Nitric oxide may contribute to cancer by turning off genes, study finds
That disruption could produce serious health effects, particularly if the genes affected promote or suppress the progression of cancer Indeed, cancers with tumors expressing high levels of nitric oxide synthase — the enzyme that makes nitric oxide in cells — have a high mortality rate
- Current Advances of Nitric Oxide in Cancer and Anticancer Therapeutics
However, as the body of scientific literature grew, the role of nitric oxide within carcinogenesis has been more clearly defined Unfortunately for those seeking to make therapeutics, nitric oxide appears to have the capability to be both tumor-promoting and tumoricidal
- The role of nitric oxide in cancer | Cell Research - Nature
Increased NO-generation in a cell may select mutant p53 cells and contribute to tumour angiogenesis by upregulating VEGF In addition, NO may modulate tumour DNA repair mechanisms by
- Nitric oxide and cancer: a review - PMC
NO has been suggested to modulate different cancer-related events [8] However, several lines of research have indicated that NO may have dual effects in cancer At concentrations measurable in many different types of clinical samples, NO seems to promote tumor growth and proliferation
- Nitric oxide and tumor metabolic reprogramming - ScienceDirect
Evidence is rapidly accumulating that metabolic reprogramming is a major new aspect of NO biology and this review is aimed to summarize recent research progress on this novel feature that expands the complex and multifaceted role of NO in cancer
- Immunomodulatory roles of nitric oxide in cancer: tumor . . .
In recent years, an increasing number of studies have shown that there is an important connection between nitric oxide (NO) and the pathology of malignant diseases, but we are far from a complete comprehension of how this simple diatomic molecule contributes to tumorigenesis
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