- Cutaneous Disorders Associated with Castlemans Disease
Although various skin manifestations have been reported to occur in Castleman's disease, a comprehensive study of cutaneous disorders in Castleman's disease is lacking Therefore, the aim of this study was to investigate Castleman's disease-associated cutaneous disorders
- Cutaneous Disorders Associated with Castleman’s Disease
Skin manifestations, including paraneoplastic pemphigus (PNP), POEMS, xanthoma, KS, etc , are known to occur in up to 55% of patients with CD However, the previous studies are all case reports and no comprehensive clinical study has been conducted (8)
- POEMS syndrome - DermNet
Darkened skin colour (hyperpigmentation) has been seen in about 50–90% patients with POEMS syndrome This is most commonly diffuse but can be localised It most frequently affects the extensor surfaces, neck, axilla and back
- POEMS syndrome and Castleman disease - American Society of Hematology
A diagnosis of POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) syndrome was made She was treated with cyclophosphamide and dexamethasone With four cycles of treatment, she regained upper extremity strength and is now ventilator independent
- POEMS-associated Multicentric Castleman Disease: A diagnostic and . . .
Castleman disease is a rare clinical entity described as a polyclonal lymphoid proliferation, that leads to generalized lymphadenopathy It is rarely presented in association with POEMS Syndrome
- Frontiers | Castleman disease variant of POEMS syndrome without M . . .
We report a case of a Castleman disease variant of POEMS syndrome without monoclonal protein (M protein) expression, which presented with polyneuropathy, organomegaly, endocrinopathy, skin lesions, and sclerotic bone lesions
- Comprehensive Diagnosis and Management of POEMS Syndrome
Such patients may have received a Castleman disease-approved agent such as siltuximab; however, this treatment is not recommended in the POEMS setting, 21 in which siltuximab is seldom effective and the priority is to target the underlying plasma cell clone
- POEMS Syndrome: Presented as Idiopathic Multicentric Castleman Disease . . .
Background: POEMS syndrome (POEMS) is a rare plasma cell clonal paraneoplastic syndrome consisting of polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes presenting with idiopathic multicentric Castleman disease (iMCD)
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