- FoldX force field revisited, an improved version - PubMed
Here, we have manually curated a database of 5556 mutants affecting protein stability, resulting in 2484 highly confident mutations denominated FoldX stability dataset (FSD), represented in non-redundant X-ray structures with <2 5 Å resolution, not involving duplicates, metals, or prosthetic groups
- FoldX force field revisited, an improved version | Bioinformatics . . .
Here, we leverage a 5556 mutant dataset of protein stabilities as described in the paper of Montanucci et al (2019) and Nikam et al (2021) to improve FoldX force field
- FoldX force field revisited, an improved version
FoldX is a software based on a rigid-solid approach where the backbone doesn't change upon mutation FoldX forcefield was trained with a dataset of changes in stability for 1000 experimentally measured point mutations (Guerois et al 2002) and their cor-responding crystal structures
- FoldX Force Field revisited, an improved version | Request PDF
Using this database, we have created a new version of the FoldX force field by introducing Pi stacking, pH dependency for all charged residues, improving aromatic-aromatic interactions,
- FoldX Force Field revisited, an improved versio. . . - Scoop. it
These changes have led to significant improvements for the prediction of specific mutants involving the above residues interactions and a statistically significant increase of FoldX predictions, as well as for the majority of the 20 aa
- FoldX Force Field revisited, an improved version - 科研通
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- FoldX force field revisited, an improved version . . .
Here, we have manually curated a database of 5556 mutants affecting protein stability, resulting in 2484 highly confident mutations denominated FoldX stability dataset (FSD), represented in non-redundant X-ray structures with <2 5 Å resolution, not involving duplicates, metals, or prosthetic groups
- FoldX Force Field revisited, an improved version - Oxford Academic
These changes have led to significant improvements for the prediction of specific mutants involving the above residues interactions and a statistically significant increase of FoldX predictions, as well as for the majority of the 20 aa
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