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  • JCI - Welcome
    In this issue of the JCI, Khan et al investigated FATP2 in glycemic control In db db mice, global FATP2 deletion reduced plasma glucose via sustained insulin secretion, with expression restricted to pancreatic α cells
  • JCI - About the Journal of Clinical Investigation
    You may submit manuscripts for consideration solely by the JCI or select the Dual-Journal Submission option to have your manuscript evaluated by the JCI and JCI Insight Start your submission by accessing your JCI author account If you don’t have an account yet, sign up here
  • JCI - Welcome
    Volume 135, Issue 23November 17, 2025
  • JCI - Author Information Center
    JCI is a Gold Open Access journal and deposits all published research articles in PubMed Central, which satisfies the NIH Public Access Policy and other similar funding agency requirements
  • JCI - Volume 135, Issue 23
    Ramzan et al report that changes in the carboxypeptidase D gene cause congenital hearing loss by harming inner ear cells and suggest a potential therapeutic strategy targeting the nitric oxide pathway The cover art is a modified version of confocal micrographs showing immunolabeled neuronal membranes, cap rods, scolopale rods, and actin bundles within the cilium in Johnston’s organ, a
  • JCI - Deep immunophenotyping reveals circulating activated lymphocytes . . .
    JCI Insight 2016;1 (17):e90045 View this article via: JCI Insight CrossRef PubMed Google Scholar Mankia K, et al EULAR points to consider for conducting clinical trials and observational studies in individuals at risk of rheumatoid arthritis Ann Rheum Dis 2021;80 (10):1286–1298 View this article via: CrossRef PubMed Google Scholar
  • JCI Insight - Welcome
    Rodrigo M Florentino, … , Deepak Nagrath, Alejandro Soto-Gutierrez Published October 21, 2025 Citation Information: JCI Insight 2025; 10 (23):e193805 https: doi org 10 1172 jci insight 193805
  • JCI Insight - About JCI Insight
    JCI Insight is a peer-reviewed journal dedicated to biomedical research, ranging from preclinical to clinical studies JCI Insight is a Gold Open Access journal that has a 2023 Impact Factor of 6 3




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