- Structured Exercise after Adjuvant Chemotherapy for Colon Cancer
Preclinical and observational studies suggest that exercise may improve cancer outcomes However, definitive level 1 evidence is lacking In this phase 3, randomized trial conducted at 55 centers,
- Tirzepatide for Heart Failure with Preserved Ejection Fraction and . . .
GLP-1RA versus placebo in patients with heart failure and mildly reduced or preserved ejection fraction: An updated meta-analysis of randomized controlled trials, International Journal of
- Coadministered Cagrilintide and Semaglutide in Adults with Overweight . . .
A total of 3417 participants underwent randomization, with 2108 assigned to receive cagrilintide–semaglutide, 302 to receive semaglutide, 302 to receive cagrilintide, and 705 to receive placebo
- Zongertinib in Previously Treated - The New England Journal of Medicine
In cohort 1, a total of 75 patients received zongertinib at a dose of 120 mg At the data cutoff (November 29, 2024), 71% of these patients (95% confidence interval [CI], 60 to 80; P<0 001 against
- Imlunestrant with or without Abemaciclib in Advanced Breast Cancer
In a phase 3, open-label trial, we enrolled patients with ER-positive, human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer that recurred or progressed during or after
- Mitochondrial Donation and Preimplantation Genetic Testing for mtDNA . . .
Clinical pregnancies were confirmed in 8 of 22 patients (36%) and 16 of 39 patients (41%) who underwent an intracytoplasmic sperm injection procedure for pronuclear transfer or for PGT, respectively
- Once-Monthly Maridebart Cafraglutide for the Treatment of Obesity — A . . .
We conducted a phase 2, double-blind, randomized, placebo-controlled, dose-ranging trial that included 11 groups as two cohorts Participants with obesity (obesity cohort) were randomly assigned
- Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis
Despite treatment advances in lupus nephritis, including regulatory approvals of belimumab and voclosporin, 1,2 the goal to sufficiently improve short- and long-term outcomes in patients with
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