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- LIAS Gene - GeneCards | LIAS Protein | LIAS Antibody
LIAS (Lipoic Acid Synthetase) is a Protein Coding gene Diseases associated with LIAS include Hyperglycinemia, Lactic Acidosis, And Seizures and Lipoic Acid Synthetase Deficiency Among its related pathways are Metabolism of proteins and Protein lipoylation
- Science 铜死亡 | 铜离子通过靶向三羧酸循环途径中的脂酰化蛋白诱导细胞死亡 - 知乎
上游是通过CRISPR-Cas9 功能缺失筛选找到了上游调节因子FDX1及LIAS，证明了铜死亡跟FDX1和蛋白脂酰化有关系。 然后提出了铜离子能结合脂酰化蛋白形成寡聚体，进而影响TCA循环。 这里面除了TCA循环，因为FDX1本身的功能，他们还提出FDX1还调控铁硫簇蛋白表达。
- 硫辛酸合成酶（LIAS）基因 | MCE
Localized in the mitochondrion, this iron-sulfur enzyme catalyzes the final step in the de novo pathway for the biosynthesis of lipoic acid, a potent antioxidant The deficient expression of this enzyme has been linked to conditions such as diabetes, atherosclerosis and neonatal-onset epilepsy
- Structural basis for catalysis by human lipoyl synthase
In this work authors present structures of LIAS captured in multiple catalytic states, revealing critical conformational changes associated with the reaction
- LIAS抗体 (ab246917)| Abcam中文官网
The biological target LIAS also known as lipoic acid synthase plays an important role in the synthesis of lipoic acid LIAS is an enzyme with a molecular mass of approximately 40 kDa and it is present in many tissues showing high expression in liver and kidney
- LIAS 基本信息 | Sino Biological
LIAS Protein Function Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
- 与LIAS基因有关的疾病 - 八方基因
LIAS基因，也被称为LAS，全名是lipoic acid synthetase，中文名为脂酸合成酶。 这个基因位于我们的4号染色体上，具体来说是在4p14这个位置。 它是一个编码蛋白质的基因，意味着它会指导合成一种特定的蛋白质。 LIAS基因的主要功能是合成脂酸（lipoic acid），这是一种非常重要的辅酶，参与多种细胞代谢过程。 脂酸在细胞中扮演着“万能钥匙”的角色，能够帮助细胞进行能量代谢、抗氧化防御以及信号传导等多种功能。 因为这些功能，LIAS基因对维持细胞健康和正常生理功能至关重要。 尽管LIAS基因在正常生理过程中扮演着重要角色，但当这个基因出现问题时，可能会导致一些疾病。 目前，与LIAS基因相关的疾病主要包括：
- lias, n. meanings, etymology and more | Oxford English Dictionary
lias, n meanings, etymology, pronunciation and more in the Oxford English Dictionary
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