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- PCSK9 function and physiology - PMC
PCSK9 was initially identified as a new member of the proprotein convertase family and suggested to have a role in liver regeneration and the differentiation of cortical neurons (14)
- What is PCSK9 and the role of PCSK9 inhibitors - Heartcare Sydney
PCSK9 is a protein that plays a pivotal role in cholesterol homeostasis It acts primarily by binding to the LDL receptors (LDLRs) on the surface of liver cells
- PCSK9 - Wikipedia
As a negative post-translational regulator of the low-density lipoprotein receptor (LDLR), PCSK9 plays a major role in cholesterol homeostasis Upon binding of low-density lipoprotein (LDL) cholesterol to the LDL receptor, the resulting LDLR-LDL complex is internalized
- Targeting proprotein convertase subtilisin kexin type 9 (PCSK9): from . . .
Proprotein convertase subtilisin kexin type 9 (PCSK9) has evolved as a pivotal enzyme in lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its related
- Understanding the PCSK9 Gene: Functions and Implications for . . .
The PCSK9 gene is a genetic variant that plays a crucial role in the regulation of cholesterol levels in the bloodstream It provides instructions for making a protein known as proprotein convertase subtilisin kexin type 9 (PCSK9), which is primarily produced in the liver
- The Role of Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) in . . .
This non-systematic review summarizes the data present to date and pertaining to the emerging role of PCSK9 in the different aspect of cardiovascular homeostasis focusing on dyslipidemia, glomerular proteinuria, insulin secretion, blood pressure regulation and inflammation
- Regulation of PCSK9 Expression and Function: Mechanisms and . . . - PubMed
Proprotein convertase subtilisin kexin type 9 (PCSK9) promotes degradation of low-density lipoprotein receptor (LDLR) and plays a central role in regulating plasma levels of LDL cholesterol levels, lipoprotein (a) and triglyceride-rich lipoproteins, increasing the risk of cardiovascular disease
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