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- Multiphysics pharmacokinetic model for targeted nanoparticles
We describe the steady-state or continuous temporal biodistribution of ICAM-1 targeted NP for a murine model in each case
- Multiphysics pharmacokinetic model for targeted nanoparticles
The purpose of this study was to develop a physics-based multiscale PBPK compartmental model for determining continuous NP biodistribution We successfully developed two versions of a physics-based compartmental model, models A and B, and validated the models with experimental data
- Multiphysics modeling and simulation of local transport and absorption . . .
Herein, we developed a bottom-up multiphysics computational model to simulate the injection and absorption processes of LNPs in muscular tissues Our purpose was to seek underlying connections between formulation attributes and local exposure kinetics of LNPs and the delivered drug
- Physiologically Based Pharmacokinetic Modeling of Nanoparticles
Nanoparticles can be engineered to have different properties such as size, shape, charge, and surface chemistry,2 thus providing a versatile platform for modifying the delivery and pharmacological performance of the loaded drugs From a formulation perspective, various nanoparticles have been used to modify the release pro le fi
- Physiologically Based Multiphysics Pharmacokinetic Model for . . .
A branched model was developed to enable the model to account for varying NP sizes With the help of the branched model, we were able to show that branching in vasculature causes enhanced
- Multiphysics pharmacokinetic model for targeted nanoparticles
The goal of the compartmental model is to develop a basic framework for determining targeted NP biodistribution in a murine model that can act as a predictive model when provided with experimentally and empirically derived parameters
- Multiphysics pharmacokinetic model for targeted nanoparticles
A branched model was developed to enable the model to account for varying NP sizes With the help of the branched model, we were able to show that branching in vasculature causes enhanced uptake
- Physiologically Based Multiphysics Pharmacokinetic Model for . . .
The purpose of this study was to develop a physics-based multiscale PBPK compartmental model for determining continuous NP biodistribution We successfully developed two versions of a physics-based compartmental model, models A and B, and validated the models with experimental data
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