- Neurotrophic Tyrosine Receptor Kinase (NTRK) Fusion . . . - Genentech
Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are an actionable biomarker for cancer therapy and can be found in over 25 different types of cancer, regardless of where they are located in the body 1,2
- NTRK fusion-positive cancers and TRK inhibitor therapy - PMC
NTRK gene fusions involving either NTRK1, NTRK2, or NTRK3 (encoding the neurotrophin receptors TRKA, TRKB, and TRKC, respectively) are oncogenic drivers of various adult and paediatric tumour types
- NTRK - Overview: NTRK Gene Fusion Panel, Tumor - Mayo Clinic Laboratories
The assay was designed to detect the most common NTRK gene fusions and novel gene fusion partners in the targeted gene regions For more information see NTRK RNA Targeted Gene Fusions
- Definition of NTRK gene fusion - NCI Dictionary of Cancer Terms
NTRK gene fusions lead to abnormal proteins called TRK fusion proteins, which may cause cancer cells to grow NTRK gene fusions may be found in some types of cancer, including cancers of the brain, head and neck, thyroid, soft tissue, lung, and colon
- NTRK and Lung Cancer - American Lung Association
NTRK gene fusions are present in many different types of cancer but are rare in lung cancer, accounting for less than 1% of all lung cancer cases However, there is an effective treatment for NTRK gene fusions in lung cancer, so it is very important to know if a patient has one
- What is NTRK positive (NTRK+) Lung Cancer?
If you have non-small cell lung cancer and your tumor tested positive for the NTRK biomarker, you have NTRK+ (NTRK positive) lung cancer This fact sheet explains what this means and how it may affect lung cancer treatment
- Oncogenic fusions: Targeting NTRK - ScienceDirect
One significant mutation driving oncogenesis in various cancers, including NSCLC, is the neurotrophic tyrosine receptor kinase (NTRK) fusion Presently, larotrectinib and entrectinib are the only FDA-approved therapies for NTRK-mutated cancers
- NTRK Patient Community Support | NTRK Fusion | NTRKers
A NTRK gene fusion in cancer is like an accelerator getting stuck, causing cancerous cells to grow NTRK (neurotrophic tyrosine receptor kinase) genes have an important part to play in all our bodies
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