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- The Emerging Therapeutic Targets for Scar Management: Genetic . . .
From Genetic Architecture to Scar Management The factors driving skin tissue regeneration are strongly associated with regulatory gene networks Deregulated genes are thus expected to either predispose individuals to cutaneous scarring or directly promote abnormal wound healing and scar formation
- Compression therapy affects collagen type balance in . . .
Type I collagen is the major component of the extracellular matrix (ECM), whereas type III collagen is the predominant collagen type in the healing wound [18] Excessive collagen deposition has been implicated in the pathogenesis of hypertrophic scar
- The Impact of Age and Genetics on Scarring and Wound Healing
Young skin produces collagen rapidly and abundantly, promoting healing and scar formation as it supports the repaired tissue Aged skin experiences a decline in collagen synthesis, leading to slower wound closure and weaker scar formation
- FACTORS AFFECTING WOUND HEALING - KorAcademy
During healing, a complex cascade of cellular events occur to achieve resurfacing, reconstitution and restoration of tensile strength of injured tissue 1 Inflammatory phase The replacement of granulation tissue with a scar involves changes in the composition of the ECM
- Why Do Scars Look Different From Surrounding Skin? | Healing . . .
Scars differ due to variations in collagen production, skin texture, and pigmentation during the healing process When skin is injured, the body produces collagen in a disorganized manner, leading to a scar that lacks the flexibility and strength of healthy tissue, resulting in visible differences
- Unraveling the Mysteries: The Science of Scar Formation
Striking a balance in collagen production is vital for achieving optimal healing without excessive scarring (or lack thereof) Individual genetic makeup can influence the propensity to form certain types of scars Understanding one’s genetic predisposition aids in predicting and managing scar outcomes
- Genetic Influences on Scar Formation: Why Some People Scar . . .
Studies have pinpointed genes that affect fibroblast activity, collagen alignment, and inflammatory responses, all of which play roles in scar formation Genetic testing for these markers can help predict an individual's scarring tendencies, allowing for personalized treatment plans
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