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- Pharmacology of carvedilol: rationale for use in hypertension . . . - PubMed
The vasodilatory effects of carvedilol reduce afterload, and the resulting decrease in impedance to left ventricular ejection offsets the negative inotropic effect that would normally result from beta-blockade
- Mechanisms Underlying Improvements in Ejection Fraction With Carvedilol . . .
Conclusions— Decreased HR, improved chamber contractility and afterload reduction each contributed significantly to improved EF with carvedilol
- Carvedilol as the new non‐selective beta . . . - Wiley Online Library
In one of the first studies on the effects of carvedilol on portal pressure conducted by Banares et al, 38 authors evaluated the acute reduction in HVPG 1 hour after carvedilol (fixed dose at 25 mg) administration compared to propranolol
- How does carvedilol reduce portal hypertension? Mechanisms explained
Carvedilol lowers portal pressure through a dual blocking mechanism involving both beta- and alpha-1 receptors It decreases cardiac output and constricts splanchnic vessels while also reducing intrahepatic resistance, resulting in a more potent hemodynamic effect than traditional beta-blockers
- Pharmacology of carvedilol - American Journal of Cardiology
In addition to these well-known properties, carvedilol has a number of ancillary activities, including antioxidant, anti-inflammatory, and antiapoptotic properties
- Results of Therapy With Carvedilol, a β-Blocker Vasodilator With . . .
The antioxidant properties of this compound are significantly greater than those of vitamin E In animal models, carvedilol may slow the process of atherogenesis, reduce infarct size, and improve postinfarction survival to a greater degree than other β-blockers
- Carvedilol in hypertension treatment - PMC
In contrast with conventional β-blockers, carvedilol maintains cardiac output, has a less extended effect on heart rate and reduces BP by decreasing vascular resistance
- Hemodynamic Differences Between Metoprolol and Carvedilol in . . .
Acutely, both drugs lowered systolic blood pressure and heart rate Whereas metoprolol reduced cardiac output and increased both systemic and femoral artery resistance, carvedilol did not alter cardiac output but led to reductions in the systemic and regional resistances
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