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- Autoimmune disorders: How a treatment involving B cells may help
Scientists are studying checkpoints in the immune system involving B cells for potential new treatments Some studies have also found an association between vitamin D and autoimmune diseases
- Pathophysiology Ch 3 Flashcards - Quizlet
Immunoglobulins that provide the ability to recognize foreign organisms stimulating the antigen-antibody reaction are called B-cells The group of diseases that occur when antibodies develop and begin to destroy the body's own cells is autoimmune diseases
- Frontiers | B cell depletion therapies in autoimmune diseases . . .
In this review, we update our understanding of B cell depletion therapies in autoimmune diseases, review the mechanism, efficacy, safety and application of monoclonal antibodies and CAR-based immunotherapies, and discuss the strengths and weaknesses of these treatment options for patients
- B cell depletion therapies in autoimmune disease: advances and . . .
Originally conceived as a method of eliminating cancerous B cells, BCDTs such as those targeting CD20, CD19 and BAFF are now used to treat autoimmune diseases, including systemic lupus
- B cells help CD8+ T-cell responses | Blood - American Society of Hematology
In this issue of Blood, Guo et al used an anti-CD20 monoclonal antibody (mAb) in a murine model of immune thrombocytopenia (ITP) to show for the first time that B-cell depletion therapy inhibits splenic CD8 + T-cell proliferation and rescues T-cell–mediated ITP 1
- B-cell depletion in autoimmune diseases - Annals of the Rheumatic Diseases
In autoimmune disease, B cells orchestrate antigen presentation, cytokine production and autoantibody production, the latter via their differentiation into antibody-secreting plasmablasts and plasma cells This article addresses the current therapeutic strategies to deplete B cells in order to ameliorate or potentially even cure autoimmune disease
- B Cell Depletion: The Latest Information on Disease Processes . . .
ACR Convergence 2020 —Because B cells play many roles in autoimmune diseases, rheumatologists have long explored B cell depletion as a reasonable strategy for the treatment of autoimmune diseases
- Research Reveals Potential Target for Immune Diseases
Now, the scientists have found that PI3Kγ plays an essential role in allowing activated B cells, a type of immune cell, to differentiate into antibody-secreting cells Beyond helping to understand disease from rare cases of human PI3Kγ deficiency, the researchers hope that other patients can also benefit from this new knowledge
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