- New Players on the Parkinsons Field | ALZFORUM
The rationale for Staropoli's study was based on known associations of parkin homologs, which contain the so-called RING domain, a small section of amino acids that interacts with the F-box and WD domains of other proteins, such as hSel-10 When Staropoli et al expressed parkin and hSel-10 together in cultured cells, they found the proteins bound tightly The authors confirmed this
- Research Models Search | ALZFORUM
Find A Model By Name Go Search Research Models Species Mouse Rat Disease Alzheimer's Disease Amyotrophic Lateral Sclerosis Cerebral Amyloid Angiopathy Down's Syndrome Frontotemporal Dementia Nasu-Hakola Disease Parkinson's Disease Gene ABCA7 APLP2 APOE APP ATG16L1 ATP13A2 BACE1 BACE2 C9orf72 CEACAM1 CLASP2 CR1 CR2 FUS GBA1 IL1RAP ITM2B (BRI2) KIF21B LRRK2 MAPT MAPT-AS1 MTHFR NOS2 PARK7 (DJ1
- Abnormal Mitochondrial Dynamics—Early Event in AD, PD?
Furthermore, parkin translocates to damaged mitochondria, triggering their autophagy (aka mitophagy) (Narendra et al , 2008) As reported in PLoS Biology, Youle, first author Derek Narendra, and colleagues did a series of biochemistry experiments that show how Pink1 helps parkin sense flagging mitochondria in the first place
- Society for Neuroscience Annual Meeting 2000 | ALZFORUM
Comments References Further Reading Society for Neuroscience Annual Meeting: Synuclein and Parkin Roundup Reported by Benjamin Wolozin, Natalie Golts and Peter Choi, Loyola University Medical Center The meeting in New Orleans demonstrated that the biology of α-synuclein and parkin are progressing at a rapid pace
- Research Models | ALZFORUM
This database provides information about selected rodent models of neurodegenerative disease, including Alzheimer’s, Parkinson’s, and ALS By summarizing, visualizing, and continuously updating available characterization data, we aim to help researchers learn, compare, and identify models that
- Parkinsonism and impaired axonal transport in a mouse model of . . .
The paper by Whitworth and colleagues adds to the work of Plun-Favreau suggesting that there is a relationship between the PINK1 parkin pathway and HtrA2 (aka Omi) Some of the data are very interesting, such as Fgure 4 which shows a change in processing of PINK1 in the absence of the protease Rhomboid-7
- PINK1 G309D (PINK1- -) Mouse (KI) | ALZFORUM
Moreover, Parkin-mediated mitophagy was unaffected in the mitochondrial fraction of PINK1- - hearts that were treated with FCCP, a mitochondrial uncoupler, or following myocardial infarction This may be due to the increased baseline levels of Parkin in heart tissue, including an increased mitochondrial localization of Parkin
- prion protein (6H4) - ALZFORUM
Parkin ET, Watt NT, Hussain I, Eckman EA, Eckman CB, Manson JC, Baybutt HN, Turner AJ, Hooper NM Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein
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