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- Pattern recognition receptors in health and diseases | Signal . . .
Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged
- Extracellular pattern recognition molecules in health and diseases
Pattern recognition receptors such as Toll-like receptors (TLRs), NOD-like receptors and RIG-I like receptors are well documented cell-associated PRMs that sense microbial components on the cell surface, in the cytoplasm or in the nucleus of immune or non-immune cells to initiate the innate response to eliminate the invading pathogens 1,2
- Self-regulation and cross-regulation of pattern-recognition receptor . . .
In the initiation of innate immune responses against pathogens, pattern-recognition receptors (PRRs) have an essential role in recognizing specific components of microorganisms and triggering responses that eliminate the invading microorganisms
- Pattern Recognition Receptors in Immune Defense: An Overview
These receptors identify pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), initiating an immune response to protect the body from infections and diseases Understanding PRRs is important as they form the first line of defense against pathogens, highlighting their role in innate immunity
- Pattern recognition receptors in health and diseases - Nature
In this review, we describe the structural characteristics, ligand recognition mechanism, the signaling pathway, the related disease, new drugs in clinical trials, and clinical therapy of
- International Union of Basic and Clinical Pharmacology. XCVI. Pattern . . .
PRRs play critically important roles in pathogen recognition to initiate innate immune responses that ultimately link to the generation of adaptive immunity Activation of PRRs leads to the induction of immune and inflammatory genes, including proinflammatory cytokines and chemokines
- An Overview of PRR- and NLR-Mediated Immunities: Conserved . . . - MDPI
Cell-surface-localized pattern recognition receptors (PRRs) and intracellular nucleotide-binding domain and leucine-rich repeat receptors (NLRs) are plant immune proteins that trigger an orchestrated downstream signaling in response to molecules of microbial origin or host plant origin Historically, PRRs have been associated with pattern-triggered immunity (PTI), whereas NLRs have been
- Anti-Viral Pattern Recognition Receptors as Therapeutic Targets
Pattern recognition receptors (PRRs) play a central role in the inflammation that ensues following microbial infection by their recognition of molecular patterns present in invading microorganisms but also following tissue damage by recognising molecules released during disease states
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