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- Pathology Outlines - PAX8
Differentiate primary pulmonary carcinomas (PAX8-) from PAX8+ metastatic carcinomas (renal, Müllerian, thyroid) (Appl Immunohistochem Mol Morphol 2019 Feb;27:140) Differentiate renal collecting duct carcinoma (PAX8+ p63-) from urothelial carcinoma of the upper urinary tract (PAX8- p63+) (Am J Surg Pathol 2010;34:965)
- Pathology Outlines - Stains CD markers
P glycoprotein p16 p21 p40 p53 p57 p62 (pending) p63 p120 catenin P504S Pan-TRK PAP PAS PAX2 PAX5 PAX8 PCNA PD-1 PDL1 22C3 PDL1 SP142 PDL1 SP263 (pending) PECAM1 perforin (pending) PGP9 5 (pending) PHLDA1 (pending) phosphohistone H3 Pit1 PLAG1 PLAP PMS2 podoplanin PRAME prealbumin (pending) progesterone receptor (PR) prostein PROX1 (pending
- Pathology Outlines - Anaplastic thyroid carcinoma
B TTF1 negative, thyroglobulin negative, PAX8 positive, cytokeratin positive Anaplastic thyroid carcinoma (ATC) is usually immunonegative for TTF1 and thyroglobulin but expresses PAX8; cytokeratin is variably positive Answer E is incorrect because vimentin can also be variably positive in ATC but in this case thyroglobulin is positive as well
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- Pathology Outlines - Diffuse mesothelioma (pleura)
Be aware that PAX8 can be positive in a small subset of malignant pleural mesothelioma Answer B is false; CAM5 2 and WT1 will be positive in both, malignant pleural mesothelioma and metastatic ovarian carcinoma; MOC31 will be expressed in metastatic carcinoma but can be at least focally expressed in malignant pleural mesothelioma
- Pathology Outlines - Mesonephric adenocarcinoma
B PAX8+, ER-, GATA3+, napsin A- Mesonephric carcinomas of the cervix are typically PAX8+, ER-, GATA3+ and napsin A- Answers A and D are incorrect because they typically show negative to focal staining for napsin A and AMACR Comment Here Reference: Mesonephric adenocarcinoma
- Pathology Outlines - Clear cell carcinoma
Usually positive for CK7, PAX8, napsin A and HNF1β and negative for ER, PR and WT1, with aberrant p53 expression in up to 24% of cases May be associated with endometriosis or Lynch syndrome Stage is the most important prognostic factor
- Pathology Outlines - Nephrogenic metaplasia adenoma
Positive for NKX3 1 and PSA but negative for PAX8 and CK7 Especially atrophic variant of prostate adenocarcinoma: Not associated with genitourinary trauma Infiltrative, more atypia No adjacent urothelium present, no thyroidization, usually no inflammation (Am J Surg Pathol 2001;25:802) Clear cell adenocarcinoma of the bladder:
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