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- Pathology Outlines - PAX8
Stains molecular markers - PAX8; 1 of 9 members of paired box gene (PAX) family of transcription factors that regulate organogenesis
- Pathology Outlines - High grade serous carcinoma
The tumor cells are positive for CK7 and PAX8 with abnormal (overexpression) of p53 but negative for CK20 Estrogen receptor and progesterone receptor expression is negative These features are best characterized as high grade serous carcinoma which displays a SET (solid, pseudoendometrioid or transitional) pattern
- Pathology Outlines - Stains CD markers
Immunostains, routine stains and CD markers at PathologyOutlines com
- Pathology Outlines - Clear cell carcinoma
Clear cell carcinoma of the ovary is a malignant tumor with distinct cellular patterns, including clear, eosinophilic, or hobnail cells
- Pathology Outlines - Renal cell carcinoma (RCC)
While the immunohistochemistry profile is not entirely concordant with a renal primary, especially with negative PAX8 and CAIX, the positivity of both CD10 and RCC Ma would suggest possibility of renal primary in the context of known history of renal cell carcinoma Clinical and radiological correlation is recommended
- Pathology Outlines - Vimentin
Comment: Immunohistochemistry positive for vimentin, PAX8, CAIX and RCC and negative for CK7 Left lung, tumor, excision: Consistent with metastatic endometrioid carcinoma (see comment) Comment: Immunohistochemistry positive for vimentin, PAX8 and ER and negative for TTF1, consistent with endometrial primary
- Mesonephric-like adenocarcinoma (uterus ovary)
Mesonephric-like adenocarcinoma (MLA) is a rare, recently recognized but frequently misdiagnosed, subtype of gynecologic malignancy arising in the ovary and uterine corpus
- Pathology Outlines - Clear cell
PAX8 is positive in both Mesothelioma: Positive for calretinin, mesothelin and CK5 6 Hemangioblastoma: Lack nuclear atypia, prominent nucleoli and necrosis PAX8 negative and inhibin positive (opposite to clear cell RCC) PAX8 negative at extrarenal sites but can be positive in kidney (Appl Immunohistochem Mol Morphol 2019;27:477)
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