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- The efficacy and safety of prokinetic agents in critically ill patients . . .
Prokinetic agents are used for treating non-critically ill patients with gastroparesis [6 – 8] The use of these agents in the ICU, although common, is based on unclear evidence Metoclopramide, erythromycin and domperidone are the commonest prokinetic agents
- Should we stop prescribing metoclopramide as a prokinetic drug in . . .
As with metoclopramide, the use of erythromycin as a prokinetic drug to improve gastric emptying is off-label Erythromycin is generally considered effective and some investigators suggest that erythromycin is even more effective than metoclopramide as a single prokinetic agent [13], [31]
- Prokinetic agents in critical care | Critical Care | Full Text
Prokinetic agents are commonly used in intensive care, mainly to aid in early enteral feeding The present commentary reviews some of the recently published papers and highlights the lack of a sizable evidence base, as well as the possible importance of euglycaemia in this important clinical area
- Erythromycin for prokinesis: imprudent prescribing?
Prokinetic agents are routinely used in patients with inappropriate gastrointestinal motility The use of erythromycin at sub-therapeutic doses as a prokinetic agent is a cause of concern for the following reasons: it can increase the emergence and spread of antibiotic resistance and the likelihood of Clostridium difficile disease
- Metoclopramide or domperidone improves post-pyloric placement of spiral . . .
Introduction The use of prokinetic agents on post-pyloric placement of spiral nasojejunal tubes is controversial The aim of the present study was to examine if metoclopramide or domperidone can increase the success rate of post-pyloric placement of spiral nasojejunal tubes Methods A multicenter, open-label, randomized, controlled trial was conducted in seven hospitals in China between April
- Do we need new prokinetics to reduce enteral feeding intolerance during . . .
Until robust study results in critically ill patients comparing new prokinetic agents with commonly used prokinetics have shown the safety and efficacy of these new promotility agents, we still have to rely on metoclopramide and erythromycin as prokinetics to improve feeding performance in patients at high risk for aspiration and critical
- Benefit of prokinetics during enteral nutrition: still searching for a . . .
The efficacy and safety of prokinetic agents in critically ill patients receiving enteral nutrition: a systematic review and meta-analysis of randomized trials
- Effect of erythromycin on mortality and the host response in critically . . .
By using prospective observational data to emulate a pragmatic RCT, we here aimed to estimate the effect of treatment with low-dose erythromycin (administered as a prokinetic agent) on mortality rate up to day 90 and the host response in critically ill patients with sepsis
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