RFdiffusion3 now available – Institute for Protein Design RFdiffusion3 tackles research challenges that have stymied protein engineers for decades Building proteins that bind to specific DNA sequences — key for gene regulation and genome editing — has required researchers to specify the exact position of every atom in the molecules they wish to create
RFdiffusion3: Protein design at all-atom resolution He added that the team realised they could repurpose AF3’s predictive framework into a generative system for design, as has been done for RosettaFold -> RFdiffusion1, RF2aa -> RFdiffusion2 and now AF3 (RF3) -> RFdiffusion3