- Semaglutide - ALZFORUM
Semaglutide is a synthetic, long-acting analog of glucagon-like peptide-1, used to treat diabetes Ozempic TM is a once-per-week injection formulation, while Rybelsus TM is is a daily pill
- The Discovery and Development of Liraglutide and Semaglutide . . . - ALZFORUM
Knudsen LB, Lau J The Discovery and Development of Liraglutide and Semaglutide Front Endocrinol (Lausanne) 2019;10:155 Epub 2019 Apr 12 PubMed
- ALZFORUM | NETWORKING FOR A CURE
A large proteogenomic study identified 49 pQTLs, in either CSF or plasma, linked to cerebral small vessel disease Immune and ECM proteins predominated
- Could GLP-1 Receptor Agonists Like Semaglutide Treat Addiction . . .
Rubin R Could GLP-1 Receptor Agonists Like Semaglutide Treat Addiction, Alzheimer Disease, and Other Conditions? JAMA 2024 May 14;331 (18):1519-1521 PubMed
- Semaglutide ameliorates Alzheimers disease and restores oxytocin in . . .
Zhang Y, Tang C, He Y, Zhang Y, Li Q, Zhang T, Zhao B, Tong A, Zhong Q, Zhong Z Semaglutide ameliorates Alzheimer's disease and restores oxytocin in APP PS1 mice and human brain organoid models
- ALZFORUM | NETWORKING FOR A CURE
Chang YF, Zhang D, Hu WM, Liu DX, Li L Semaglutide-mediated protection against Aβ correlated with enhancement of autophagy and inhibition of apotosis J Clin Neurosci 2020 Nov;81:234-239 Epub 2020 Oct 14 PubMed Recommends Please login to recommend the paper
- Empagliflozin - ALZFORUM
Empagliflozin belongs to the gliflozin class of glucose-lowering agents that includes dapagliflozin These drugs inhibit the sodium-glucose cotransporter-2 (SGLT2), which is responsible for 90 percent of glucose reabsorption into the kidney As a result, excess glucose is secreted via the urine, helping reduce blood glucose, alleviate glucose toxicity, improve insulin sensitivity, and promote
- Diabetes Drug Shows Promise for Parkinson’s Disease
Importantly, the beneficial effects seen are likely to be restricted to those GLP1 receptor agonists which can effectively access the brain, as has been demonstrated for exenatide (and are likely for the closely structurally related lixisenatide), but do not occur with liraglutide or semaglutide, while it remains unclear for the PEGylated
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