- Semaglutide - ALZFORUM
Semaglutide is a synthetic, long-acting analog of glucagon-like peptide-1, used to treat diabetes Ozempic TM is a once-per-week injection formulation, while Rybelsus TM is is a daily pill
- The Discovery and Development of Liraglutide and Semaglutide . . . - ALZFORUM
Knudsen LB, Lau J The Discovery and Development of Liraglutide and Semaglutide Front Endocrinol (Lausanne) 2019;10:155 Epub 2019 Apr 12 PubMed
- ALZFORUM | NETWORKING FOR A CURE
A large proteogenomic study identified 49 pQTLs, in either CSF or plasma, linked to cerebral small vessel disease Immune and ECM proteins predominated
- Could GLP-1 Receptor Agonists Like Semaglutide Treat Addiction . . .
Rubin R Could GLP-1 Receptor Agonists Like Semaglutide Treat Addiction, Alzheimer Disease, and Other Conditions? JAMA 2024 May 14;331 (18):1519-1521 PubMed
- Semaglutide is Neuroprotective and Reduces α-Synuclein Levels in the . . .
Zhang L, Zhang L, Li L, Hölscher C Semaglutide is Neuroprotective and Reduces α-Synuclein Levels in the Chronic MPTP Mouse Model of Parkinson's Disease J Parkinsons Dis 2019;9 (1):157-171
- Exploring the Impact of Semaglutide on Cognitive Function and Anxiety . . .
Boboc IK, Dumitrelea PD, Meca AD, Mititelu-Tartau L, Bogdan M Exploring the Impact of Semaglutide on Cognitive Function and Anxiety-Related Behaviors in a Murine Model of Alzheimer's Disease
- Semaglutide ameliorates Alzheimers disease and restores oxytocin in . . .
Zhang Y, Tang C, He Y, Zhang Y, Li Q, Zhang T, Zhao B, Tong A, Zhong Q, Zhong Z Semaglutide ameliorates Alzheimer's disease and restores oxytocin in APP PS1 mice and human brain organoid models
- Diabetes Drug Shows Promise for Parkinson’s Disease
Importantly, the beneficial effects seen are likely to be restricted to those GLP1 receptor agonists which can effectively access the brain, as has been demonstrated for exenatide (and are likely for the closely structurally related lixisenatide), but do not occur with liraglutide or semaglutide, while it remains unclear for the PEGylated
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