|
- Persistence and Toxin Production by Clostridium difficile within Human . . .
Here, we asked if human intestinal organoids (HIOs), which are derived from pluripotent stem cells and demonstrate small intestinal morphology and physiology, could be used to study the pathogenesis of the obligate anaerobe C difficile
- Differential effects of Clostridium difficile toxins on ion secretion . . .
Toxin A (TcdA), toxin B (TcdB), and binary toxin (CDT) produced by Clostridium difficile (CD) are thought to play a key role in inducing diarrhea The aim of this study was to investigate the
- Clostridioides difficile Toxins: Host Cell Interactions and Their Role . . .
Toxins damage the colonic epithelium, initiating a cascade of cellular events that lead to inflammation, fluid secretion, and further tissue damage within the colon
- Clostridioides difficile infection: traversing host–pathogen . . .
Abstract C difficile is the primary cause for nosocomial infective diarrhoea For a successful infection, C difficile must navigate between resident gut bacteria and the harsh host environment
- Microbes and Microbial Toxins: Paradigms for Microbial- Mucosal . . .
C difficile toxin A exerts its potent secretory and necroinflammatory responses in mammalian intestine by a separate neural pathway involving the activation of mucosal mast cells and release of SP and CGRP from sensory neurons
- Frontiers | Characterization of the Adherence of Clostridium difficile . . .
In this context, we sought to characterize the adherence properties of spores from an epidemic C difficile strain to components of the intestinal mucosa, such as intestinal epithelial cell lines, porcine stomach mucin, fibronectin and vitronectin
- Reinforcement of the Intestinal Mucus Layer Protects Against
Clostridium difficile infection is increasing in incidence and severity Attributable factors include virulence factors, including C difficile toxins A and B, as well as host immunologic status The mucus component of the intestinal barrier is impaired by malnutrition, shock insults, and alterations in the gut microbiome
- Mucin-Degrading Microbes Release Monosaccharides That Chemoattract . . .
C difficile was found to chemotax toward intestinal mucus and its glycan components, demonstrating that C difficile senses the mucus layer
|
|
|