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- Rethinking TREM2 as a target for Alzheimer’s disease after . . . - Nature
When Alector announced in late 2024 that its phase 2 trial of AL002, a monoclonal antibody that targets TREM2, had failed to slow cognitive decline in Alzheimer’s disease (AD), it reignited
- TREM2 and sTREM2 in Alzheimer’s disease: from mechanisms to therapies
Recent studies have established TREM2 as a central immune signaling hub in neurodegeneration, where it triggers immune responses upon sensing pathological development and tissue damages
- TREM2 in Alzheimers disease: Structure, function, therapeutic . . .
Triggering receptor expressed on myeloid cells 2 (TREM2) is a membrane glycoprotein that plays a crucial role in the regulation of microglial survival, activation, phagocytosis, as well as in the maintenance of brain homeostasis and the inflammatory response to injury or neurodegeneration
- TREM2 | ALZFORUM
Triggering receptor expressed on myeloid cells 2 (TREM2) is a receptor of the innate immune system expressed on microglia, macrophages, dendritic cells, and osteoclasts TREM2 is a member of the immunoglobulin superfamily
- The Physiology, Pathology, and Potential Therapeutic Applications of . . .
In this review, we summarize and question what is known and remains to be discovered about TREM2 signaling pathway, track the consequences of its activation in physiological niches and pathological contexts, and highlight the promising potential of therapeutic manipulation of TREM2 signaling
- TREM2 — a key player in microglial biology and Alzheimer disease
Variations in triggering receptor expressed on myeloid cells 2 (TREM2), one of several genes for which expression is restricted to microglia in the brain, have now been shown to increase the risk
- TREM2-ligand interactions in health and disease - PMC
Triggering receptor expression on myeloid cells-2 (TREM2) is an extracellular innate immune receptor expressed on myeloid lineage cells such as dendritic cells (DC) and resident tissue macrophages (including osteoclasts and microglia)
- Alveolar macrophage cell surface receptor TREM2 promotes lung fibrosis
The UAB researchers showed that TREM2 — which stands for triggering receptors expressed on myeloid cells 2 — is predominantly expressed on monocyte-derived alveolar macrophages in bleomycin-induced fibrotic mouse lungs They also found that TREM2 was significantly elevated on lung macrophages from patients with idiopathic pulmonary fibrosis
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