EMCrit 380 – Acid Base Part VIII – Tris-Hydroxymethyl . . . Tris-Hydroxymethyl Aminomethane (THAM or tromethamine) is an amino alcohol that acts as a buffer base that unlike NaBicarb doesn't increase Na or release CO2–it actually lowers PaCO2 Sounds great, huh? It is unfortunately expensive and has some other issues we will discuss
Tromethamine (THAM) Discontinuation - Stanford Health Care THAM is often used in place of sodium bicarbonate because THAM lacks the carbon-dioxide producing effects of bicarbonate THAM is capable of buffering both metabolic and respiratory acids which leads to an increase in extracellular and intracellular pH without carbon dioxide generation
Tris - Wikipedia Medical Tris (usually known as THAM in this context) is used as alternative to sodium bicarbonate in the treatment of metabolic acidosis [16][17]
THAM (tromethamine injection) | Pfizer Medical - US Tham Solution (tromethamine injection) is administered by slow intravenous infusion, by addition to pump-oxygenator ACD blood or other priming fluid or by injection into the ventricular cavity during cardiac arrest