|
- The benefits of GLP1 receptors in cardiovascular diseases
The aim of this article is to provide a comprehensive review of GLP-1 receptor agonists impact on cardiovascular outcomes and risk reduction In the last decade, several cardiovascular outcomes trials (CVOT) have been conducted in order to explore cardiovascular benefit of GLP-1 receptor agonists
- GLP-1 Receptor Agonists for the Reduction of Atherosclerotic . . .
Patients with type 2 diabetes are at high risk for development of cardiovascular disease, including myocardial infarction, stroke, heart failure, and cardiovascular death Multiple large cardiovascular outcome trials with novel glucose-lowering agents, namely SGLT2i (SGLT2 inhibitors) and GLP-1 RA (GLP-1 receptor agonists), have demonstrated robust and significant reductions of major adverse
- Semaglutide and Cardiovascular Outcomes in Obesity without . . .
Semaglutide, a glucagon-like peptide-1 receptor agonist, has been shown to reduce the risk of adverse cardiovascular events in patients with diabetes Whether semaglutide can reduce cardiovascular
- Glucagon-like peptide 1 receptor agonists: cardiovascular . . .
In this Review, Ussher and Drucker discuss the possible mechanisms of cardiovascular benefit of GLP1 receptor agonists and highlight the novel GLP1-based multi-agonists currently in development
- Time-dependent effect of GLP-1 receptor agonists on . . .
Background Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shown cardiovascular benefits in cardiovascular outcome trials in type 2 diabetes mellitus However, the most convincing evidence was obtained in subjects with established cardiovascular (CV) disease We analyzed the determinants of GLP-1 RA-mediated CV protection in a real-world population of persons with type 2 diabetes
- Cardiovascular benefits of GLP-1 agonists in type 2 diabetes . . .
Contrary to the assertions that (a) all GLP-1 agonists reduce CV disease in T2D but to different extents or (b) the magnitude of CV protection is predominantly related to glucose-lowering, we argue that CV benefit is specific to agents that provide longer acting agonism at the GLP-1 receptor
- Metabolic and cardiovascular benefits of GLP-1 agonists . . .
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as a new antidiabetic drug class with multiple metabolic effects Some trials have evaluated their safety, but it has been recently demonstrated that this new class has cardiovascular benefits, through other mechanisms than glycemic control
- Can one drug do it all? Reviewing the expanding clinical . . .
Landmark trials have shown that GLP-1 receptor agonists, originally developed for diabetes and weight loss, also provide significant benefits for cardiovascular, kidney, liver, joint, and sleep
|
|
|