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- Which psychotropics carry the greatest risk of QTc prolongation? - MDedge
Clinical Point QTc prolongation has been reported with all SSRIs at plasma concentrations above the therapeutic level
- Addressing QTc Prolongation With Antipsychotics - U. S. Pharmacist
The mean change in QTc interval of ziprasidone reported 15 9 msec, haloperidol reported 7 1 msec, and quetiapine reported 5 7 msec Risperidone had a mean change in QTc prolongation of 3 9 msec at the 6-mg day dosage and 3 6 msec at the 8-mg day dosage
- Risperidone, QTc interval prolongation, and torsade de pointes: a . . .
Rationale: A recent publication asserted that even low-dose risperidone may induce corrected QT (QTc) interval prolongation up to 500 ms without drug-induced IKr blockade
- Guidelines for the Management of QTc Prolongation in Adults Prescribed . . .
Do you have alternative medication options open to you if the current regime needs to be changed because of excessive prolongation in the QT-interval?
- Risperidone, QTc interval prolongation, and torsade de . . . - Springer
Doyle and Rosenthal (2013) concluded that risperi-done is linked to minor increases in the QTc interval when taken in therapeutic doses and when taken in overdose TdP has been reported with risperidone in monotherapy and when this antipsychotic drug has been combined with other drugs
- Which atypical antipsychotics are associated with the lowest and . . .
Atypical antipsychotics consistently associated with the highest risk of QTc prolongation include ziprasidone and iloperidone Those associated with a relatively moderate risk include olanzapine, quetiapine, and risperidone Finally, lurasidone and aripiprazole appear to confer the lowest risk of QTc prolongation
- QTc Prolongation With Antidepressants and Antipsychotics
Clinicians should strive to use antipsychotics or antidepressants with a lower risk of QTc prolongation in patients with multiple risk factors for this adverse event
- Guidelines for the Management of QTc Prolongation with . . . - TEWV
Many drug therapies are associated with prolongation of the QT interval This is an independent risk factor for developing Torsades de Pointes (TdP), a potentially life-threatening cardiac arrhythmia, and sudden cardiac-related death
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