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- The neurosteroid pregnenolone promotes degradation of key proteins in . . .
A decreased level of pregnenolone has been observed in neuroinflammatory diseases, which emphasizes its role in neuroprotection and neuroregeneration Although the anti-inflammatory property of pregnenolone was recognized several decades ago, its mechanism of action remains unknown
- Function, regulation, and pharmacological effects of pregnenolone in . . .
Evidence for its therapeutic potential has emerged following studies reporting altered pregnenolone levels in psychiatric and pain disorders, as well as therapeutic benefits of pregnenolone adjunct therapy in these conditions
- The neurosteroid pregnenolone promotes degradation of key proteins in . . .
We investigated the effect of pregnenolone and its metabolic derivatives, such as pregnenolone sulfate, allopregnanolone, and progesterone, on secretion of TNFα by mouse and human macrophages and mouse microglial cells
- Pregnenolone and Progesterone in Reproductive Health - European Society . . .
This narrative literature review aimed to integrate findings from molecular biology, clinical medicine, and translational research on pregnenolone and progesterone
- New USC Mann Study Unlocks the Potential of Neurosteroids
A new study, published in The Journal of Biological Chemistry in August 2023, reveals how the brain produces pregnenolone—the “mother hormone” that is the progenitor of all neurosteroids
- Pregnenolone: Benefits, Side Effects, Dosage, and Interactions
If you're considering a pregnenolone supplement, it's helpful to know what research says about the benefits it can provide It's also important to consider pregnenolone's potential side effects and warnings, enabling you to decide better if it is the right option for you
- Pregnenolone in Menopause and Major Depressive Disorder and . . . - ICH GCP
Pregnenolone is a precursor of hormones known to fluctuate during the menopausal transition, and may decrease this hormonal variability known to increase the risk of MDD Preclinical research suggests that pregnenolone has antidepressant and neuroprotective effects, and improves cognition
- Proof-of-Concept Trial with the Neurosteroid Pregnenolone Targeting . . .
We therefore investigated adjunctive pregnenolone for cognitive and negative symptoms in patients with schizophrenia or schizoaffective disorder receiving stable doses of second-generation antipsychotics in a pilot randomized, placebo-controlled, double-blind trial
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