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- Membrane versus soluble isoforms of TNF α exert opposing effects on . . .
Although TNFα can exist as one of two isoforms, a 26-kDa membrane tethered form (mTNFα) or a soluble 17-kDa cytokine (sTNFα), the vast majority of published studies have only investigated the biological effects of the soluble form
- The expression pattern of membranous TNF-α is distinct from its . . .
Tumor necrosis factor-alpha (TNF-α) is mostly known as a soluble cytokine This study, however, focused on its membranous form whose significance is rarely investigated in antitumor immunity
- Tumor necrosis factor - Wikipedia
Tumor necrosis factor (TNF), formerly known as TNF-α, is a chemical messenger produced by the immune system that induces inflammation [5] TNF is produced primarily by activated macrophages, and induces inflammation by binding to its receptors on other cells [6]
- The TNF Alpha Pathway: Its Role in Health and Disease
Tumor Necrosis Factor-alpha (TNF-alpha) is a signaling protein (cytokine) central to the body’s immune system It plays a role in both maintaining health and contributing to disease when its activity becomes imbalanced
- Transmembrane TNF-alpha: structure, function and interaction . . . - PubMed
Transmembrane TNF-alpha acts as a bipolar molecule that transmits signals both as a ligand and as a receptor in a cell-to-cell contact fashion
- Human TNF Alpha: Significance in Immunology and Disease
TNF alpha, or tumor necrosis factor-alpha, stands as a crucial player in the immune system, influencing numerous physiological and pathological processes Without a solid grasp on TNF alpha, understanding modern immunology and pathology becomes a daunting task
- Tumor Necrosis Factor (TNF): How Does It Cause Inflammation? - WebMD
Your system gets flooded with inflammation, which often means you have too much tumor necrosis factor – specifically, a type called TNF alpha
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