- TREM2 - ALZFORUM
TREM2 encodes Triggering Receptor Expressed on Myeloid Cells 2, a transmembrane receptor that modulates microglial activity and survival TREM2 variants cause Nasu-Hakola disease (NHD), a rare autosomal recessive early-onset dementia, and may modify the risk of developing Alzheimer’s disease (AD), frontotemporal dementia (FTD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis
- TREM2 drives microglia response to amyloid-β via SYK-dependent and . . .
Zhao P, Xu Y, Fan X, Li L, Li X, Arase H, Tong Q, Zhang N, An Z Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice MAbs 2022 Jan-Dec;14 (1):2107971 PubMed View all comments by Josh Morganti Ana Griciuc Massachusetts General Hospital and Harvard Medical School Rudy Tanzi Massachusetts General Hospital 03 Nov 2022 News: SYK It
- Changing With the Times: Disease Stage Alters TREM2 Effect on Tau
Variants in the TREM2 gene increase the chances of getting Alzheimer’s disease by two- to fourfold Scientists have done much digging to figure out how this transmembrane receptor influences microglial responses to Aβ plaques Now, two groups report how it influences the second major hallmark of
- TREM2, humanized (R47H) - ALZFORUM
These humanized TREM2 mice were created in a two-step process: First, transgenic mice were generated that carry BACs containing the R47H variant of human TREM2 including its regulatory elements, TREML1, and TREML2 Then these BAC transgenic mice were backcrossed to Trem2 - - mice (Turnbull et al , 2006) A second BAC transgenic line, TREM2 CV, was created in parallel TREM2 CV mice express the
- TREM2-IPD | ALZFORUM
Summary Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) is a transmembrane receptor found on microglia, where it modulates cell activity and survival In addition to membrane-associated TREM2, there are soluble forms of the protein—generated by protease cleavage of the extracellular domain or expression of alternative transcripts that lack a transmembrane domain
- LILRB2-mediated TREM2 signaling inhibition suppresses microglia . . .
Zhao P, Xu Y, Jiang LL, Fan X, Ku Z, Li L, Liu X, Deng M, Arase H, Zhu JJ, Huang TY, Zhao Y, Zhang C, Xu H, Tong Q, Zhang N, An Z LILRB2-mediated TREM2 signaling
- TREM2 variants in Alzheimers disease. | ALZFORUM
Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation Brain 2008 Nov;131 (Pt 11):3081-91
- TREM2 expression level is critical for microglial state, metabolic . . .
Feiten AF, Dahm K, vanLengerich B, Suh JH, Reifschneider A, Wefers B, Bartos LM, Wind-Mark K, Schlepckow K, Ulas T, De-Domenico E, Becker M, Khalin I, Davis SS, Wurst W, Plesnila N, Neher JJ, Brendel M, Lewcock JW, DiPaolo G, Capell A, Monroe KM, Schultze JL, Haass C TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism 2024 Jul 22 10 1101
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