- Afterload promotes maturation of human induced pluripotent stem cell . . .
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) grown in engineered heart tissue (EHT) can be used for drug screening, disease modeling, and heart repair However, the immaturity of hiPSC-CMs currently limits their use Because mechanical loading increases during development and facilitates cardiac maturation, we hypothesized that afterload would promote maturation of
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